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1tub

From Proteopedia

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{{Seed}}
 
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[[Image:1tub.png|left|200px]]
 
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==TUBULIN ALPHA-BETA DIMER, ELECTRON DIFFRACTION==
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The line below this paragraph, containing "STRUCTURE_1tub", creates the "Structure Box" on the page.
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<StructureSection load='1tub' size='340' side='right'caption='[[1tub]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tub]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. The July 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Microtubules'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_7 10.2210/rcsb_pdb/mom_2014_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TUB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron crystallography, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=TXL:TAXOTERE'>TXL</scene></td></tr>
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{{STRUCTURE_1tub| PDB=1tub | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tub OCA], [https://pdbe.org/1tub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tub RCSB], [https://www.ebi.ac.uk/pdbsum/1tub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tub ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TBA1A_PIG TBA1A_PIG] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tu/1tub_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tub ConSurf].
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<div style="clear:both"></div>
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===TUBULIN ALPHA-BETA DIMER, ELECTRON DIFFRACTION===
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==See Also==
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*[[Tubulin 3D Structures|Tubulin 3D Structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9428769}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9428769 is the PubMed ID number.
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[[Category: Microtubules]]
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[[Category: RCSB PDB Molecule of the Month]]
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{{ABSTRACT_PUBMED_9428769}}
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==About this Structure==
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1TUB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUB OCA].
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==Reference==
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Structure of the alpha beta tubulin dimer by electron crystallography., Nogales E, Wolf SG, Downing KH, Nature. 1998 Jan 8;391(6663):199-203. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9428769 9428769]
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[[Category: Protein complex]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Downing, K H.]]
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[[Category: Downing KH]]
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[[Category: Nogales, E.]]
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[[Category: Nogales E]]
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[[Category: Alpha-tubulin]]
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[[Category: Beta-tubulin]]
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[[Category: Gtpase]]
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[[Category: Microtubule]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:22:41 2008''
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Current revision

TUBULIN ALPHA-BETA DIMER, ELECTRON DIFFRACTION

PDB ID 1tub

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