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2gwo

From Proteopedia

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{{Seed}}
 
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[[Image:2gwo.png|left|200px]]
 
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==crystal structure of TMDP==
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The line below this paragraph, containing "STRUCTURE_2gwo", creates the "Structure Box" on the page.
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<StructureSection load='2gwo' size='340' side='right'caption='[[2gwo]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gwo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GWO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gwo OCA], [https://pdbe.org/2gwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gwo RCSB], [https://www.ebi.ac.uk/pdbsum/2gwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gwo ProSAT]</span></td></tr>
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{{STRUCTURE_2gwo| PDB=2gwo | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DS13B_HUMAN DS13B_HUMAN] Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.<ref>PMID:21360282</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/2gwo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gwo ConSurf].
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<div style="clear:both"></div>
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===crystal structure of TMDP===
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==See Also==
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*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_17044055}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 17044055 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_17044055}}
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==About this Structure==
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2GWO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWO OCA].
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==Reference==
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Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity., Kim SJ, Jeong DG, Yoon TS, Son JH, Cho SK, Ryu SE, Kim JH, Proteins. 2007 Jan 1;66(1):239-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17044055 17044055]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kim, J H.]]
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[[Category: Kim JH]]
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[[Category: Kim, S J.]]
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[[Category: Kim SJ]]
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[[Category: Ryu, S E.]]
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[[Category: Ryu SE]]
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[[Category: Alpha/beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:30:48 2008''
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Current revision

crystal structure of TMDP

PDB ID 2gwo

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