This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1qxz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:18, 14 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1qxz.png|left|200px]]
 
-
<!--
+
==Crystal structure of S. aureus methionine aminopeptidase in complex with a ketoheterocycle inhibitor 119==
-
The line below this paragraph, containing "STRUCTURE_1qxz", creates the "Structure Box" on the page.
+
<StructureSection load='1qxz' size='340' side='right'caption='[[1qxz]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1qxz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QXZ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=M3C:(2S)-2-AMINO-4-(METHYLSULFANYL)-1-(1,3-THIAZOL-2-YL)BUTANE-1,1-DIOL'>M3C</scene></td></tr>
-
{{STRUCTURE_1qxz| PDB=1qxz | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qxz OCA], [https://pdbe.org/1qxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qxz RCSB], [https://www.ebi.ac.uk/pdbsum/1qxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qxz ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MAP1_STAAM MAP1_STAAM]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qx/1qxz_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qxz ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of S. aureus methionine aminopeptidase in complex with a ketoheterocycle inhibitor 119===
+
==See Also==
-
 
+
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_14998322}}, adds the Publication Abstract to the page
+
[[Category: Large Structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 14998322 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_14998322}}
+
-
 
+
-
==About this Structure==
+
-
1QXZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXZ OCA].
+
-
 
+
-
==Reference==
+
-
Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate., Douangamath A, Dale GE, D'Arcy A, Almstetter M, Eckl R, Frutos-Hoener A, Henkel B, Illgen K, Nerdinger S, Schulz H, Mac Sweeney A, Thormann M, Treml A, Pierau S, Wadman S, Oefner C, J Med Chem. 2004 Mar 11;47(6):1325-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14998322 14998322]
+
-
[[Category: Methionyl aminopeptidase]]
+
-
[[Category: Single protein]]
+
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
-
[[Category: Arcy, A D.]]
+
[[Category: D'Arcy A]]
-
[[Category: Dale, G E.]]
+
[[Category: Dale GE]]
-
[[Category: Douangamath, A.]]
+
[[Category: Douangamath A]]
-
[[Category: Oefner, C.]]
+
[[Category: Oefner C]]
-
[[Category: Pita bread fold]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:46:18 2008''
+

Current revision

Crystal structure of S. aureus methionine aminopeptidase in complex with a ketoheterocycle inhibitor 119

PDB ID 1qxz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qxz"
Personal tools