3b4d

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{{Seed}}
 
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[[Image:3b4d.png|left|200px]]
 
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==Crystal Structure of Human PABPN1 RRM==
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The line below this paragraph, containing "STRUCTURE_3b4d", creates the "Structure Box" on the page.
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<StructureSection load='3b4d' size='340' side='right'caption='[[3b4d]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3b4d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B4D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.001&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4d OCA], [https://pdbe.org/3b4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b4d RCSB], [https://www.ebi.ac.uk/pdbsum/3b4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b4d ProSAT]</span></td></tr>
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{{STRUCTURE_3b4d| PDB=3b4d | SCENE= }}
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</table>
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== Disease ==
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===Crystal Structure of Human PABPN1 RRM===
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[https://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN] Defects in PABPN1 are the cause of oculopharyngeal muscular dystrophy (OPMD) [MIM:[https://omim.org/entry/164300 164300]. OPMD is a form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement.<ref>PMID:9462747</ref> <ref>PMID:12673802</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PABP2_HUMAN PABP2_HUMAN] Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).<ref>PMID:11689481</ref> <ref>PMID:11371506</ref>
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==About this Structure==
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== Evolutionary Conservation ==
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3B4D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4D OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==Reference==
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<jmolCheckbox>
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Crystal structure and possible dimerization of the single RRM of human PABPN1., Ge H, Zhou D, Tong S, Gao Y, Teng M, Niu L, Proteins. 2008 May 15;71(3):1539-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18275081 18275081]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/3b4d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b4d ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ge, H.]]
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[[Category: Ge H]]
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[[Category: Niu, L.]]
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[[Category: Niu L]]
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[[Category: Teng, M.]]
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[[Category: Teng M]]
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[[Category: Tong, S.]]
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[[Category: Tong S]]
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[[Category: Acetylation]]
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[[Category: Alpha-beta sandwich structure]]
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[[Category: Alternative splicing]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasm]]
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[[Category: Disease mutation]]
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[[Category: Methylation]]
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[[Category: Mrna processing]]
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[[Category: Nucleus]]
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[[Category: Polymorphism]]
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[[Category: Rna binding domain]]
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[[Category: Rna binding protein]]
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[[Category: Rna recognition motif]]
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[[Category: Rna-binding]]
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[[Category: Rrm fold]]
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[[Category: Triplet repeat expansion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:47:48 2008''
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Current revision

Crystal Structure of Human PABPN1 RRM

PDB ID 3b4d

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