2nov

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{{Seed}}
 
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[[Image:2nov.png|left|200px]]
 
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==Breakage-reunion domain of S.pneumoniae topo IV: crystal structure of a gram-positive quinolone target==
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The line below this paragraph, containing "STRUCTURE_2nov", creates the "Structure Box" on the page.
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<StructureSection load='2nov' size='340' side='right'caption='[[2nov]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2nov]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NOV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nov OCA], [https://pdbe.org/2nov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nov RCSB], [https://www.ebi.ac.uk/pdbsum/2nov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nov ProSAT]</span></td></tr>
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{{STRUCTURE_2nov| PDB=2nov | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q3HYJ3_STREE Q3HYJ3_STREE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/no/2nov_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nov ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The 2.7 A crystal structure of the 55-kDa N-terminal breakage-reunion domain of topoisomerase (topo) IV subunit A (ParC) from Streptococcus pneumoniae, the first for the quinolone targets from a gram-positive bacterium, has been solved and reveals a 'closed' dimer similar in fold to Escherichia coli DNA gyrase subunit A (GyrA), but distinct from the 'open' gate structure of Escherichia coli ParC. Unlike GyrA whose DNA binding groove is largely positively charged, the DNA binding site of ParC exhibits a distinct pattern of alternating positively and negatively charged regions coincident with the predicted positions of the grooves and phosphate backbone of DNA. Based on the ParC structure, a new induced-fit model for sequence-specific recognition of the gate (G) segment by ParC has been proposed. These features may account for the unique DNA recognition and quinolone targeting properties of pneumococcal type II topoisomerases compared to their gram-negative counterparts.
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===Breakage-reunion domain of S.pneumoniae topo IV: crystal structure of a gram-positive quinolone target===
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Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target.,Laponogov I, Veselkov DA, Sohi MK, Pan XS, Achari A, Yang C, Ferrara JD, Fisher LM, Sanderson MR PLoS ONE. 2007 Mar 21;2(3):e301. PMID:17375187<ref>PMID:17375187</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2nov" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17375187}}, adds the Publication Abstract to the page
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17375187 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17375187}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2NOV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NOV OCA].
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==Reference==
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Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target., Laponogov I, Veselkov DA, Sohi MK, Pan XS, Achari A, Yang C, Ferrara JD, Fisher LM, Sanderson MR, PLoS ONE. 2007 Mar 21;2(3):e301. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17375187 17375187]
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[[Category: Single protein]]
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[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
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[[Category: Achari, A.]]
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[[Category: Achari A]]
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[[Category: Ferrara, J D.]]
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[[Category: Ferrara JD]]
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[[Category: Fisher, L M.]]
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[[Category: Fisher LM]]
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[[Category: Laponogov, I.]]
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[[Category: Laponogov I]]
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[[Category: Pan, X S.]]
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[[Category: Pan XS]]
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[[Category: Sanderson, M R.]]
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[[Category: Sanderson MR]]
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[[Category: Sohi, M K.]]
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[[Category: Sohi MK]]
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[[Category: Veselkov, D A.]]
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[[Category: Veselkov DA]]
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[[Category: Yang, C.]]
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[[Category: Yang C]]
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[[Category: Dna binding]]
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[[Category: Dna cleavage]]
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[[Category: Gram-positive bacteria]]
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[[Category: Parc]]
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[[Category: Protein]]
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[[Category: Quinolone target]]
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[[Category: Topo iv]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:59:09 2008''
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Current revision

Breakage-reunion domain of S.pneumoniae topo IV: crystal structure of a gram-positive quinolone target

PDB ID 2nov

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