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1klx

From Proteopedia

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(New page: 200px<br /><applet load="1klx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1klx, resolution 1.950&Aring;" /> '''Helicobacter pylori...)
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[[Image:1klx.gif|left|200px]]<br /><applet load="1klx" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1klx, resolution 1.950&Aring;" />
 
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'''Helicobacter pylori cysteine rich protein B (hcpB)'''<br />
 
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==Overview==
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==Helicobacter pylori cysteine rich protein B (hcpB)==
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Colonization of the gastric mucosa with the spiral-shaped Gram-negative, proteobacterium Helicobacter pylori is probably the most common chronic, infection in humans. The genomes of H. pylori strains J99 and 26695 have, been completely sequenced. Functional and three-dimensional structural, information is available for less than one third of all open reading, frames. We investigated the function and three-dimensional structure of a, member from a family of cysteine-rich hypothetical proteins that are, unique to H. pylori and Campylobacter jejuni. The structure of H. pylori, cysteine-rich protein (Hcp) B possesses a modular architecture consisting, of four alpha/alpha-motifs that are cross-linked by disulfide bridges. The, Hcp repeat is similar to the tetratricopeptide repeat, which is frequently, found in protein/protein interactions. In contrast to the, tetratricopeptide repeat, the Hcp repeat is 36 amino acids long. HcpB is, capable of binding and hydrolyzing 6-amino penicillinic acid and 7-amino, cephalosporanic acid derivatives. The HcpB fold is distinct from the fold, of any known penicillin-binding protein, indicating that the Hcp proteins, comprise a new family of penicillin-binding proteins. The putative, penicillin binding site is located in an amphipathic groove on the concave, side of the molecule.
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<StructureSection load='1klx' size='340' side='right'caption='[[1klx]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1klx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KLX FirstGlance]. <br>
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1KLX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1klx OCA], [https://pdbe.org/1klx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1klx RCSB], [https://www.ebi.ac.uk/pdbsum/1klx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1klx ProSAT]</span></td></tr>
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==Reference==
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</table>
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The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein., Luthy L, Grutter MG, Mittl PR, J Biol Chem. 2002 Mar 22;277(12):10187-93. Epub 2002 Jan 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11777911 11777911]
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== Function ==
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[https://www.uniprot.org/uniprot/HCPB_HELPY HCPB_HELPY] Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/1klx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1klx ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Gruetter, M.G.]]
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[[Category: Gruetter MG]]
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[[Category: Luethy, L.]]
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[[Category: Luethy L]]
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[[Category: Mittl, P.R.E.]]
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[[Category: Mittl PRE]]
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[[Category: helix-turn-helix]]
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[[Category: modular structure']]
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[[Category: right handed super helix]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 19:20:58 2007''
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Current revision

Helicobacter pylori cysteine rich protein B (hcpB)

PDB ID 1klx

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