1wsr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:34, 13 March 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1wsr.png|left|200px]]
 
-
<!--
+
==Crystal Structure of Human T-protein of Glycine Cleavage System==
-
The line below this paragraph, containing "STRUCTURE_1wsr", creates the "Structure Box" on the page.
+
<StructureSection load='1wsr' size='340' side='right'caption='[[1wsr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1wsr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WSR FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1wsr| PDB=1wsr | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsr OCA], [https://pdbe.org/1wsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wsr RCSB], [https://www.ebi.ac.uk/pdbsum/1wsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wsr ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/GCST_HUMAN GCST_HUMAN] Defects in AMT are a cause of non-ketotic hyperglycinemia (NKH) [MIM:[https://omim.org/entry/605899 605899]; also known as glycine encephalopathy (GCE). NKH is an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.<ref>PMID:8005589</ref> <ref>PMID:9600239</ref> <ref>PMID:9621520</ref> <ref>PMID:10873393</ref> <ref>PMID:11286506</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GCST_HUMAN GCST_HUMAN] The glycine cleavage system catalyzes the degradation of glycine.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/1wsr_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wsr ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal Structure of Human T-protein of Glycine Cleavage System===
+
==See Also==
-
 
+
*[[Aminomethyltransferase 3D structures|Aminomethyltransferase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_16051266}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 16051266 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_16051266}}
+
-
 
+
-
==About this Structure==
+
-
1WSR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSR OCA].
+
-
 
+
-
==Reference==
+
-
Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia., Okamura-Ikeda K, Hosaka H, Yoshimura M, Yamashita E, Toma S, Nakagawa A, Fujiwara K, Motokawa Y, Taniguchi H, J Mol Biol. 2005 Sep 2;351(5):1146-59. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16051266 16051266]
+
-
[[Category: Aminomethyltransferase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Fujiwara, K.]]
+
[[Category: Fujiwara K]]
-
[[Category: Hosaka, H.]]
+
[[Category: Hosaka H]]
-
[[Category: Motokawa, Y.]]
+
[[Category: Motokawa Y]]
-
[[Category: Nakagawa, A.]]
+
[[Category: Nakagawa A]]
-
[[Category: Okamura-Ikeda, K.]]
+
[[Category: Okamura-Ikeda K]]
-
[[Category: Taniguchi, H.]]
+
[[Category: Taniguchi H]]
-
[[Category: Toma, S.]]
+
[[Category: Toma S]]
-
[[Category: Yamashita, E.]]
+
[[Category: Yamashita E]]
-
[[Category: Yoshimura, M.]]
+
[[Category: Yoshimura M]]
-
[[Category: Aminomethyl transferase]]
+
-
[[Category: Glycine-cleavage sytem]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:14:24 2008''
+

Current revision

Crystal Structure of Human T-protein of Glycine Cleavage System

PDB ID 1wsr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wsr"
Personal tools