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1wsr

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{{Seed}}
 
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[[Image:1wsr.png|left|200px]]
 
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<!--
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==Crystal Structure of Human T-protein of Glycine Cleavage System==
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The line below this paragraph, containing "STRUCTURE_1wsr", creates the "Structure Box" on the page.
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<StructureSection load='1wsr' size='340' side='right'caption='[[1wsr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wsr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WSR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1wsr| PDB=1wsr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsr OCA], [https://pdbe.org/1wsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wsr RCSB], [https://www.ebi.ac.uk/pdbsum/1wsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wsr ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GCST_HUMAN GCST_HUMAN] Defects in AMT are a cause of non-ketotic hyperglycinemia (NKH) [MIM:[https://omim.org/entry/605899 605899]; also known as glycine encephalopathy (GCE). NKH is an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.<ref>PMID:8005589</ref> <ref>PMID:9600239</ref> <ref>PMID:9621520</ref> <ref>PMID:10873393</ref> <ref>PMID:11286506</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GCST_HUMAN GCST_HUMAN] The glycine cleavage system catalyzes the degradation of glycine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/1wsr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wsr ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Human T-protein of Glycine Cleavage System===
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==See Also==
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*[[Aminomethyltransferase 3D structures|Aminomethyltransferase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_16051266}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16051266 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_16051266}}
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==About this Structure==
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1WSR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSR OCA].
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==Reference==
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Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia., Okamura-Ikeda K, Hosaka H, Yoshimura M, Yamashita E, Toma S, Nakagawa A, Fujiwara K, Motokawa Y, Taniguchi H, J Mol Biol. 2005 Sep 2;351(5):1146-59. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16051266 16051266]
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[[Category: Aminomethyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Fujiwara, K.]]
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[[Category: Fujiwara K]]
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[[Category: Hosaka, H.]]
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[[Category: Hosaka H]]
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[[Category: Motokawa, Y.]]
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[[Category: Motokawa Y]]
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[[Category: Nakagawa, A.]]
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[[Category: Nakagawa A]]
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[[Category: Okamura-Ikeda, K.]]
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[[Category: Okamura-Ikeda K]]
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[[Category: Taniguchi, H.]]
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[[Category: Taniguchi H]]
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[[Category: Toma, S.]]
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[[Category: Toma S]]
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[[Category: Yamashita, E.]]
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[[Category: Yamashita E]]
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[[Category: Yoshimura, M.]]
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[[Category: Yoshimura M]]
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[[Category: Aminomethyl transferase]]
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[[Category: Glycine-cleavage sytem]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:14:24 2008''
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Current revision

Crystal Structure of Human T-protein of Glycine Cleavage System

PDB ID 1wsr

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