2qxv

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{{Seed}}
 
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[[Image:2qxv.png|left|200px]]
 
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==Structural basis of EZH2 recognition by EED==
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The line below this paragraph, containing "STRUCTURE_2qxv", creates the "Structure Box" on the page.
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<StructureSection load='2qxv' size='340' side='right'caption='[[2qxv]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2qxv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QXV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qxv OCA], [https://pdbe.org/2qxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qxv RCSB], [https://www.ebi.ac.uk/pdbsum/2qxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qxv ProSAT]</span></td></tr>
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{{STRUCTURE_2qxv| PDB=2qxv | SCENE= }}
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</table>
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== Function ==
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===Structural basis of EZH2 recognition by EED===
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[https://www.uniprot.org/uniprot/EED_MOUSE EED_MOUSE] Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain.<ref>PMID:9234727</ref> <ref>PMID:9742080</ref> <ref>PMID:11479595</ref> <ref>PMID:12370779</ref> <ref>PMID:12689588</ref> <ref>PMID:12627233</ref> <ref>PMID:12649488</ref> <ref>PMID:15516932</ref> <ref>PMID:15916951</ref> <ref>PMID:16618801</ref> <ref>PMID:16415857</ref> <ref>PMID:17259173</ref> <ref>PMID:17997413</ref> <ref>PMID:18201968</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17937919 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qx/2qxv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17937919}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qxv ConSurf].
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2QXV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXV OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Structural basis of EZH2 recognition by EED., Han Z, Xing X, Hu M, Zhang Y, Liu P, Chai J, Structure. 2007 Oct;15(10):1306-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17937919 17937919]
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__TOC__
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[[Category: Histone-lysine N-methyltransferase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Han Z]]
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[[Category: Han, Z.]]
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[[Category: Alternative splicing]]
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[[Category: Dna-binding]]
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[[Category: Gene regulation]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation]]
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[[Category: Polycomb repressive complex 2]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Wd-repeat domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:20:39 2008''
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Current revision

Structural basis of EZH2 recognition by EED

PDB ID 2qxv

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