2z7x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:47, 7 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2z7x.png|left|200px]]
 
-
<!--
+
==Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide==
-
The line below this paragraph, containing "STRUCTURE_2z7x", creates the "Structure Box" on the page.
+
<StructureSection load='2z7x' size='340' side='right'caption='[[2z7x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2z7x]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. The November 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z7X FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PCJ:(2R)-3-{[(2S)-3-HYDROXY-2-(PALMITOYLAMINO)PROPYL]THIO}PROPANE-1,2-DIYL+DIHEXADECANOATE'>PCJ</scene></td></tr>
-
{{STRUCTURE_2z7x| PDB=2z7x | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z7x OCA], [https://pdbe.org/2z7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z7x RCSB], [https://www.ebi.ac.uk/pdbsum/2z7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z7x ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TLR2_HUMAN TLR2_HUMAN] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z7/2z7x_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z7x ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide===
+
==See Also==
-
 
+
*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
-
 
+
*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
-
<!--
+
__TOC__
-
The line below this paragraph, {{ABSTRACT_PUBMED_17889651}}, adds the Publication Abstract to the page
+
</StructureSection>
-
(as it appears on PubMed at http://www.pubmed.gov), where 17889651 is the PubMed ID number.
+
[[Category: Eptatretus burgeri]]
-
-->
+
[[Category: Homo sapiens]]
-
{{ABSTRACT_PUBMED_17889651}}
+
[[Category: Large Structures]]
-
 
+
[[Category: RCSB PDB Molecule of the Month]]
-
==About this Structure==
+
[[Category: Synthetic construct]]
-
2Z7X is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens,_eptatretus_burgeri Homo sapiens, eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z7X OCA].
+
[[Category: Toll-like Receptors]]
-
 
+
[[Category: Heo JY]]
-
==Reference==
+
[[Category: Jin MS]]
-
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide., Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO, Cell. 2007 Sep 21;130(6):1071-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17889651 17889651]
+
[[Category: Kim SE]]
-
[[Category: Homo sapiens, eptatretus burgeri]]
+
[[Category: Lee JO]]
-
[[Category: Protein complex]]
+
-
[[Category: Heo, J Y.]]
+
-
[[Category: Jin, M S.]]
+
-
[[Category: Kim, S E.]]
+
-
[[Category: Lee, J O.]]
+
-
[[Category: Cytoplasmic vesicle]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Immune response]]
+
-
[[Category: Immune system]]
+
-
[[Category: Inflammatory response]]
+
-
[[Category: Innate immunity]]
+
-
[[Category: Leucine-rich repeat]]
+
-
[[Category: Lipopeptide]]
+
-
[[Category: Membrane]]
+
-
[[Category: Pam3csk4]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Receptor]]
+
-
[[Category: Tlr1]]
+
-
[[Category: Tlr2]]
+
-
[[Category: Transmembrane]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:22:57 2008''
+

Current revision

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

PDB ID 2z7x

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2z7x"
Personal tools