4ait
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="4ait" size="450" color="white" frame="true" align="right" spinBox="true" caption="4ait" /> '''RESTRAINED ENERGY REFINEMENT WITH TWO DIFFER...) |
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| - | [[Image:4ait.gif|left|200px]]<br /><applet load="4ait" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="4ait" /> | ||
| - | '''RESTRAINED ENERGY REFINEMENT WITH TWO DIFFERENT ALGORITHMS AND FORCE FIELDS OF THE STRUCTURE OF THE ALPHA-AMYLASE INHIBITOR TENDAMISTAT DETERMINED BY NMR IN SOLUTION'''<br /> | ||
| - | == | + | ==RESTRAINED ENERGY REFINEMENT WITH TWO DIFFERENT ALGORITHMS AND FORCE FIELDS OF THE STRUCTURE OF THE ALPHA-AMYLASE INHIBITOR TENDAMISTAT DETERMINED BY NMR IN SOLUTION== |
| - | + | <StructureSection load='4ait' size='340' side='right'caption='[[4ait]]' scene=''> | |
| - | [[ | + | == Structural highlights == |
| + | <table><tr><td colspan='2'>[[4ait]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_tendae Streptomyces tendae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AIT FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ait FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ait OCA], [https://pdbe.org/4ait PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ait RCSB], [https://www.ebi.ac.uk/pdbsum/4ait PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ait ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IAA_STRTE IAA_STRTE] Inhibits mammalian alpha-amylases specifically but has no action on plant and microbial alpha-amylases. Forms a tight stoichiometric 1:1 complex with alpha-amylase. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/4ait_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4ait ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Streptomyces tendae]] | [[Category: Streptomyces tendae]] | ||
| - | [[Category: Billeter | + | [[Category: Billeter M]] |
| - | [[Category: Braun | + | [[Category: Braun W]] |
| - | [[Category: Schaumann | + | [[Category: Schaumann T]] |
| - | [[Category: Wuthrich | + | [[Category: Wuthrich K]] |
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Current revision
RESTRAINED ENERGY REFINEMENT WITH TWO DIFFERENT ALGORITHMS AND FORCE FIELDS OF THE STRUCTURE OF THE ALPHA-AMYLASE INHIBITOR TENDAMISTAT DETERMINED BY NMR IN SOLUTION
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