This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1yyb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:31, 6 December 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1yyb.png|left|200px]]
 
-
<!--
+
==Solution structure of 1-26 fragment of human programmed cell death 5 protein==
-
The line below this paragraph, containing "STRUCTURE_1yyb", creates the "Structure Box" on the page.
+
<StructureSection load='1yyb' size='340' side='right'caption='[[1yyb]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1yyb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YYB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YYB FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yyb OCA], [https://pdbe.org/1yyb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yyb RCSB], [https://www.ebi.ac.uk/pdbsum/1yyb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yyb ProSAT]</span></td></tr>
-
{{STRUCTURE_1yyb| PDB=1yyb | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PDCD5_HUMAN PDCD5_HUMAN] May function in the process of apoptosis.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
PDCD5-(1-26) is a N-terminal 26-residue fragment of human PDCD5 (programmed cell death 5) protein. PDCD5 is an important novel protein that regulates both apoptotic and non-apoptotic programmed cell death. The conformation of PDCD5 protein is a stable helical core consisting of a triple-helix bundle and two dissociated terminal regions. The N-terminal region is ordered and contains abundant secondary structure. Overexpression and purification of the N-terminal 26-residure fragment, PDCD5-(1-26), was performed in this study to better understand its tertiary structure. The spectroscopic studies using CD and hetero- and homo-nuclear NMR methods determine a stable alpha-helix formed by Asp3-Ala19 of PDCD5-(1-26). The N-terminal residues Asp3-Ala19 of PDCD5 were then affirmed to have the capacity to form a stable alpha-helix independently of the core of the protein. Analysis of the helical peptide of PDCD5-(1-26) indicates that the surface of this well-formed alpha-helix has a unique electrostatic potential character. This may provide an environment for the N-terminal alpha-helix of PDCD5 to serve as an independent functional entity of the protein. The apoptosis activity assay shows that the deletion of the N-terminal alpha-helix of PDCD5 significantly attenuates the apoptosis-promoting effects on HL-60 cells induced by serum withdrawal.
-
===Solution structure of 1-26 fragment of human programmed cell death 5 protein===
+
The N-terminal 26-residue fragment of human programmed cell death 5 protein can form a stable alpha-helix having unique electrostatic potential character.,Liu D, Yao H, Chen Y, Feng Y, Chen Y, Wang J Biochem J. 2005 Nov 15;392(Pt 1):47-54. PMID:16083422<ref>PMID:16083422</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1yyb" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_16083422}}, adds the Publication Abstract to the page
+
*[[Cell death protein 3D structures|Cell death protein 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 16083422 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_16083422}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
1YYB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YYB OCA].
+
-
 
+
-
==Reference==
+
-
The N-terminal 26-residue fragment of human programmed cell death 5 protein can form a stable alpha-helix having unique electrostatic potential character., Liu D, Yao H, Chen Y, Feng Y, Chen Y, Wang J, Biochem J. 2005 Nov 15;392(Pt 1):47-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16083422 16083422]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Feng, Y G.]]
+
[[Category: Feng YG]]
-
[[Category: Liu, D S.]]
+
[[Category: Liu DS]]
-
[[Category: Wang, J F.]]
+
[[Category: Wang JF]]
-
[[Category: Yao, H W.]]
+
[[Category: Yao HW]]
-
[[Category: Solution structure]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:47:40 2008''
+

Current revision

Solution structure of 1-26 fragment of human programmed cell death 5 protein

PDB ID 1yyb

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yyb"
Personal tools