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1veq

From Proteopedia

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{{Seed}}
 
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[[Image:1veq.png|left|200px]]
 
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<!--
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==Mycobacterium smegmatis Dps Hexagonal form==
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The line below this paragraph, containing "STRUCTURE_1veq", creates the "Structure Box" on the page.
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<StructureSection load='1veq' size='340' side='right'caption='[[1veq]], [[Resolution|resolution]] 3.98&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1veq]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis Mycolicibacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VEQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.98&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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{{STRUCTURE_1veq| PDB=1veq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1veq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1veq OCA], [https://pdbe.org/1veq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1veq RCSB], [https://www.ebi.ac.uk/pdbsum/1veq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1veq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPS_MYCSM DPS_MYCSM] Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). It protects DNA from hydroxyl radical-mediated cleavage. Binds DNA with no apparent sequence specificity without self-aggregation nor promotion of DNA condensation. Is unable to protect DNA from DNase-mediated cleavage.<ref>PMID:12466274</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/1veq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1veq ConSurf].
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<div style="clear:both"></div>
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===Mycobacterium smegmatis Dps Hexagonal form===
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==See Also==
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*[[Ferritin 3D structures|Ferritin 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15178251}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15178251 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_15178251}}
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[[Category: Mycolicibacterium smegmatis]]
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[[Category: Chatterji D]]
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==About this Structure==
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[[Category: Das S]]
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1VEQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VEQ OCA].
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[[Category: Gupta S]]
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[[Category: Roy S]]
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==Reference==
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[[Category: Sekar K]]
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X-ray analysis of Mycobacterium smegmatis Dps and a comparative study involving other Dps and Dps-like molecules., Roy S, Gupta S, Das S, Sekar K, Chatterji D, Vijayan M, J Mol Biol. 2004 Jun 18;339(5):1103-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15178251 15178251]
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[[Category: Vijayan M]]
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[[Category: Mycobacterium smegmatis]]
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[[Category: Single protein]]
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[[Category: Chatterji, D.]]
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[[Category: Das, S.]]
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[[Category: Gupta, S.]]
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[[Category: Roy, S.]]
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[[Category: Sekar, K.]]
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[[Category: Vijayan, M.]]
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[[Category: Dna-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:48:17 2008''
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Current revision

Mycobacterium smegmatis Dps Hexagonal form

PDB ID 1veq

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