2c5r

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{{Seed}}
 
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[[Image:2c5r.png|left|200px]]
 
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==The structure of phage phi29 replication organizer protein p16.7 in complex with double stranded DNA==
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The line below this paragraph, containing "STRUCTURE_2c5r", creates the "Structure Box" on the page.
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<StructureSection load='2c5r' size='340' side='right'caption='[[2c5r]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2c5r]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_virus_phi29 Bacillus virus phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C5R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5r OCA], [https://pdbe.org/2c5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c5r RCSB], [https://www.ebi.ac.uk/pdbsum/2c5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c5r ProSAT]</span></td></tr>
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{{STRUCTURE_2c5r| PDB=2c5r | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GP167_BPPH2 GP167_BPPH2] Binds to the long stretches of ssDNA of the viral DNA replication intermediates created during the protein-primed mechanism of replication of the viral genome and attaches the viral DNA to the membrane of the infected cells (PubMed:11741949) (PubMed:11169113). Required for the redistribution of replicating viral DNA from the initial replication site to membrane-associated sites surrounding the nucleoid (PubMed:10921898). Required for the second pull step of DNA ejection (PubMed:17526715).<ref>PMID:10921898</ref> <ref>PMID:11169113</ref> <ref>PMID:11741949</ref> <ref>PMID:17526715</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Prokaryotic DNA replication is compartmentalized at the cellular membrane. Functional and biochemical studies showed that the Bacillus subtilis phage 29-encoded membrane protein p16.7 is directly involved in the organization of membrane-associated viral DNA replication. The structure of the functional domain of p16.7 in complex with DNA, presented here, reveals the multimerization mode of the protein and provides insights in the organization of the phage genome at the membrane of the infected cell.
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===THE STRUCTURE OF PHAGE PHI29 REPLICATION ORGANIZER PROTEIN P16.7 IN COMPLEX WITH DOUBLE STRANDED DNA===
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Structural basis for membrane anchorage of viral phi29 DNA during replication.,Albert A, Munoz-Espin D, Jimenez M, Asensio JL, Hermoso JA, Salas M, Meijer WJ J Biol Chem. 2005 Dec 30;280(52):42486-8. Epub 2005 Nov 7. PMID:16275651<ref>PMID:16275651</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16275651}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2c5r" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16275651 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16275651}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Bacillus virus phi29]]
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2C5R is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_phage_phi29 Bacillus phage phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5R OCA].
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[[Category: Large Structures]]
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[[Category: Albert A]]
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==Reference==
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[[Category: Asensio JL]]
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Structural basis for membrane anchorage of viral phi29 DNA during replication., Albert A, Munoz-Espin D, Jimenez M, Asensio JL, Hermoso JA, Salas M, Meijer WJ, J Biol Chem. 2005 Dec 30;280(52):42486-8. Epub 2005 Nov 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16275651 16275651]
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[[Category: Hermoso JA]]
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[[Category: Bacillus phage phi29]]
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[[Category: Jimenez M]]
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[[Category: Protein complex]]
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[[Category: Meijer WJJ]]
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[[Category: Albert, A.]]
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[[Category: Munoz-Espin D]]
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[[Category: Asensio, J L.]]
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[[Category: Salas M]]
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[[Category: Hermoso, J A.]]
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[[Category: Jimenez, M.]]
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[[Category: Meijer, W J.J.]]
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[[Category: Munoz-Espin, D.]]
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[[Category: Salas, M.]]
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[[Category: Dna-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:52:42 2008''
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Current revision

The structure of phage phi29 replication organizer protein p16.7 in complex with double stranded DNA

PDB ID 2c5r

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