2br7

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{{Seed}}
 
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[[Image:2br7.png|left|200px]]
 
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==Crystal Structure of Acetylcholine-binding Protein (AChBP) from Aplysia californica in complex with HEPES==
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The line below this paragraph, containing "STRUCTURE_2br7", creates the "Structure Box" on the page.
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<StructureSection load='2br7' size='340' side='right'caption='[[2br7]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2br7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BR7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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{{STRUCTURE_2br7| PDB=2br7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2br7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2br7 OCA], [https://pdbe.org/2br7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2br7 RCSB], [https://www.ebi.ac.uk/pdbsum/2br7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2br7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/br/2br7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2br7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Conotoxins (Ctx) form a large family of peptide toxins from cone snail venoms that act on a broad spectrum of ion channels and receptors. The subgroup alpha-Ctx specifically and selectively binds to subtypes of nicotinic acetylcholine receptors (nAChRs), which are targets for treatment of several neurological disorders. Here we present the structure at a resolution of 2.4 A of alpha-Ctx PnIA (A10L D14K), a potent blocker of the alpha(7)-nAChR, bound with high affinity to acetylcholine binding protein (AChBP), the prototype for the ligand-binding domains of the nAChR superfamily. Alpha-Ctx is buried deep within the ligand-binding site and interacts with residues on both faces of adjacent subunits. The toxin itself does not change conformation, but displaces the C loop of AChBP and induces a rigid-body subunit movement. Knowledge of these contacts could facilitate the rational design of drug leads using the Ctx framework and may lead to compounds with increased receptor subtype selectivity.
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===CRYSTAL STRUCTURE OF ACETYLCHOLINE-BINDING PROTEIN (ACHBP) FROM APLYSIA CALIFORNICA IN COMPLEX WITH HEPES===
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Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.,Celie PH, Kasheverov IE, Mordvintsev DY, Hogg RC, van Nierop P, van Elk R, van Rossum-Fikkert SE, Zhmak MN, Bertrand D, Tsetlin V, Sixma TK, Smit AB Nat Struct Mol Biol. 2005 Jul;12(7):582-8. Epub 2005 Jun 12. PMID:15951818<ref>PMID:15951818</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2br7" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15951818}}, adds the Publication Abstract to the page
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*[[Acetylcholine binding protein 3D structures|Acetylcholine binding protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15951818 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15951818}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2BR7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BR7 OCA].
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==Reference==
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Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant., Celie PH, Kasheverov IE, Mordvintsev DY, Hogg RC, van Nierop P, van Elk R, van Rossum-Fikkert SE, Zhmak MN, Bertrand D, Tsetlin V, Sixma TK, Smit AB, Nat Struct Mol Biol. 2005 Jul;12(7):582-8. Epub 2005 Jun 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15951818 15951818]
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[[Category: Aplysia californica]]
[[Category: Aplysia californica]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bertrand, D.]]
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[[Category: Bertrand D]]
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[[Category: Celie, P H.N.]]
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[[Category: Celie PHN]]
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[[Category: Elk, R Van.]]
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[[Category: Hogg RC]]
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[[Category: Hogg, R C.]]
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[[Category: Kasheverov IE]]
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[[Category: Kasheverov, I E.]]
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[[Category: Mordvintsev DY]]
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[[Category: Mordvintsev, D Y.]]
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[[Category: Sixma TK]]
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[[Category: Nierop, P Van.]]
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[[Category: Smit AB]]
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[[Category: Rossum-Fikkert, S E.Van.]]
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[[Category: Tsetlin V]]
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[[Category: Sixma, T K.]]
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[[Category: Van Elk R]]
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[[Category: Smit, A B.]]
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[[Category: Van Nierop P]]
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[[Category: Tsetlin, V.]]
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[[Category: Van Rossum-Fikkert SE]]
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[[Category: Zhmak, M N.]]
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[[Category: Zhmak MN]]
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[[Category: 3d-structure]]
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[[Category: Glycoprotein]]
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[[Category: Igg-fold]]
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[[Category: Immunoglobulin domain]]
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[[Category: Nicotinic receptor]]
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[[Category: Pentamer]]
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[[Category: Receptor protein]]
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[[Category: Signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:53:14 2008''
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Current revision

Crystal Structure of Acetylcholine-binding Protein (AChBP) from Aplysia californica in complex with HEPES

PDB ID 2br7

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