1pq3

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{{Seed}}
 
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[[Image:1pq3.png|left|200px]]
 
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==Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal==
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The line below this paragraph, containing "STRUCTURE_1pq3", creates the "Structure Box" on the page.
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<StructureSection load='1pq3' size='340' side='right'caption='[[1pq3]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pq3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PQ3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=S2C:S-2-(BORONOETHYL)-L-CYSTEINE'>S2C</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1pq3| PDB=1pq3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pq3 OCA], [https://pdbe.org/1pq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pq3 RCSB], [https://www.ebi.ac.uk/pdbsum/1pq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pq3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pq/1pq3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pq3 ConSurf].
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<div style="clear:both"></div>
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===Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal===
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==See Also==
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*[[Arginase 3D structures|Arginase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12859189}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12859189 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12859189}}
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==About this Structure==
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1PQ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQ3 OCA].
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==Reference==
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Human arginase II: crystal structure and physiological role in male and female sexual arousal., Cama E, Colleluori DM, Emig FA, Shin H, Kim SW, Kim NN, Traish AM, Ash DE, Christianson DW, Biochemistry. 2003 Jul 22;42(28):8445-51. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12859189 12859189]
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[[Category: Arginase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ash, D E.]]
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[[Category: Ash DE]]
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[[Category: Cama, E.]]
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[[Category: Cama E]]
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[[Category: Christianson, D W.]]
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[[Category: Christianson DW]]
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[[Category: Colleluori, D M.]]
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[[Category: Colleluori DM]]
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[[Category: Emig, F A.]]
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[[Category: Emig FA]]
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[[Category: Kim, N N.]]
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[[Category: Kim NN]]
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[[Category: Kim, S W.]]
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[[Category: Kim SW]]
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[[Category: Shin, H.]]
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[[Category: Shin H]]
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[[Category: Traish, A M.]]
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[[Category: Traish AM]]
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[[Category: Biosynthetic protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:14:19 2008''
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Current revision

Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal

PDB ID 1pq3

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