1x76

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{{Seed}}
 
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[[Image:1x76.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-697==
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The line below this paragraph, containing "STRUCTURE_1x76", creates the "Structure Box" on the page.
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<StructureSection load='1x76' size='340' side='right'caption='[[1x76]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1x76]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X76 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=697:5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE'>697</scene></td></tr>
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{{STRUCTURE_1x76| PDB=1x76 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x76 OCA], [https://pdbe.org/1x76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x76 RCSB], [https://www.ebi.ac.uk/pdbsum/1x76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x76 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.
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== Function ==
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[https://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN] Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.<ref>PMID:9427757</ref> <ref>PMID:7481822</ref> <ref>PMID:9223431</ref> <ref>PMID:9296499</ref> <ref>PMID:9223281</ref> <ref>PMID:10449719</ref> <ref>PMID:12954634</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x7/1x76_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x76 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-697===
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==See Also==
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*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15548008}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15548008 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_15548008}}
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==About this Structure==
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1X76 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X76 OCA].
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==Reference==
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Structure-based design of estrogen receptor-beta selective ligands., Manas ES, Unwalla RJ, Xu ZB, Malamas MS, Miller CP, Harris HA, Hsiao C, Akopian T, Hum WT, Malakian K, Wolfrom S, Bapat A, Bhat RA, Stahl ML, Somers WS, Alvarez JC, J Am Chem Soc. 2004 Nov 24;126(46):15106-19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15548008 15548008]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Akopian, T.]]
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[[Category: Akopian T]]
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[[Category: Alvarez, J C.]]
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[[Category: Alvarez JC]]
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[[Category: Bapat, A.]]
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[[Category: Bapat A]]
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[[Category: Bhat, R A.]]
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[[Category: Bhat RA]]
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[[Category: Harris, H A.]]
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[[Category: Harris HA]]
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[[Category: Hsiao, C.]]
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[[Category: Hsiao C]]
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[[Category: Hum, W T.]]
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[[Category: Hum WT]]
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[[Category: Malakian, K.]]
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[[Category: Malakian K]]
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[[Category: Malamas, M S.]]
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[[Category: Malamas MS]]
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[[Category: Manas, E S.]]
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[[Category: Manas ES]]
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[[Category: Miller, C P.]]
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[[Category: Miller CP]]
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[[Category: Somers, W S.]]
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[[Category: Somers WS]]
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[[Category: Stahl, M L.]]
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[[Category: Stahl ML]]
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[[Category: Unwalla, R J.]]
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[[Category: Unwalla RJ]]
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[[Category: Wolfrom, S.]]
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[[Category: Wolfrom S]]
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[[Category: Xu, Z B.]]
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[[Category: Xu ZB]]
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[[Category: Agonist]]
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[[Category: Er]]
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[[Category: Er-beta]]
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[[Category: Estrogen]]
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[[Category: Estrogen receptor]]
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[[Category: Estrogen receptor beta]]
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[[Category: Nuclear receptor]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:20:20 2008''
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Current revision

CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-697

PDB ID 1x76

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