2a26

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{{Seed}}
 
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[[Image:2a26.png|left|200px]]
 
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==Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein==
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The line below this paragraph, containing "STRUCTURE_2a26", creates the "Structure Box" on the page.
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<StructureSection load='2a26' size='340' side='right'caption='[[2a26]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2a26]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A26 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2a26| PDB=2a26 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a26 OCA], [https://pdbe.org/2a26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a26 RCSB], [https://www.ebi.ac.uk/pdbsum/2a26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a26 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein===
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== Function ==
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[https://www.uniprot.org/uniprot/CYBP_HUMAN CYBP_HUMAN] May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).<ref>PMID:16085652</ref>
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16085652 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_16085652}}
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==About this Structure==
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2A26 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A26 OCA].
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==Reference==
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Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex., Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S, J Biol Chem. 2005 Oct 7;280(40):34278-87. Epub 2005 Aug 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16085652 16085652]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ely, K R.]]
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[[Category: Ely KR]]
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[[Category: Fukushima, T.]]
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[[Category: Fukushima T]]
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[[Category: Leone, M.]]
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[[Category: Leone M]]
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[[Category: Li, C.]]
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[[Category: Li C]]
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[[Category: Liddington, R C.]]
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[[Category: Liddington RC]]
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[[Category: Matsuzawa, S.]]
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[[Category: Matsuzawa S]]
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[[Category: Olson, A J.]]
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[[Category: Olson AJ]]
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[[Category: Pellecchia, M.]]
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[[Category: Pellecchia M]]
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[[Category: Preece, N E.]]
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[[Category: Preece NE]]
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[[Category: Reed, J C.]]
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[[Category: Reed JC]]
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[[Category: Santelli, E.]]
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[[Category: Santelli E]]
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[[Category: Dimerization]]
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[[Category: Helical hairpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:27:26 2008''
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Current revision

Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein

PDB ID 2a26

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