This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2jxy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:30, 27 January 2022) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2jxy.png|left|200px]]
 
-
<!--
+
==Solution structure of the hemopexin-like domain of MMP12==
-
The line below this paragraph, containing "STRUCTURE_2jxy", creates the "Structure Box" on the page.
+
<StructureSection load='2jxy' size='340' side='right'caption='[[2jxy]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2jxy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXY FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
-->
+
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr>
-
{{STRUCTURE_2jxy| PDB=2jxy | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxy OCA], [https://pdbe.org/2jxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxy RCSB], [https://www.ebi.ac.uk/pdbsum/2jxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxy ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jxy_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jxy ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The proteolytic activity of matrix metalloproteinases toward extracellular matrix components (ECM), cytokines, chemokines, and membrane receptors is crucial for several homeostatic and pathological processes. Active MMPs are a family of single-chain enzymes (23 family members in the human genome), most of which constituted by a catalytic domain and by a hemopexin-like domain connected by a linker. The X-ray structures of MMP-1 and MMP-2 suggest a conserved and well-defined spatial relationship between the two domains. Here we present structural data for MMP-12, suitably stabilized against self-hydrolysis, both in solution (NMR and SAXS) and in the solid state (X-ray), showing that the hemopexin-like and the catalytic domains experience conformational freedom with respect to each other on a time scale shorter than 10 (-8) s. Hints on the probable conformations are also obtained. This experimental finding opens new perspectives for the often hypothesized active role of the hemopexin-like domain in the enzymatic activity of MMPs.
-
===Solution structure of the hemopexin-like domain of MMP12===
+
Evidence of Reciprocal Reorientation of the Catalytic and Hemopexin-Like Domains of Full-Length MMP-12.,Bertini I, Calderone V, Fragai M, Jaiswal R, Luchinat C, Melikian M, Mylonas E, Svergun DI J Am Chem Soc. 2008 May 9;. PMID:18465858<ref>PMID:18465858</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2jxy" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_18465858}}, adds the Publication Abstract to the page
+
*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 18465858 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_18465858}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Human]]
-
2JXY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXY OCA].
+
[[Category: Large Structures]]
-
 
+
-
==Reference==
+
-
Evidence of Reciprocal Reorientation of the Catalytic and Hemopexin-Like Domains of Full-Length MMP-12., Bertini I, Calderone V, Fragai M, Jaiswal R, Luchinat C, Melikian M, Mylonas E, Svergun DI, J Am Chem Soc. 2008 May 9;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18465858 18465858]
+
-
[[Category: Homo sapiens]]
+
[[Category: Macrophage elastase]]
[[Category: Macrophage elastase]]
-
[[Category: Single protein]]
+
[[Category: Bertini, I]]
-
[[Category: Bertini, I.]]
+
[[Category: Calderone, V]]
-
[[Category: Calderone, V.]]
+
[[Category: Fragai, M]]
-
[[Category: Fragai, M.]]
+
[[Category: Jaiswal, R]]
-
[[Category: Jaiswal, R.]]
+
[[Category: Luchinat, C]]
-
[[Category: Luchinat, C.]]
+
[[Category: Melikian, M]]
-
[[Category: Melikian, M.]]
+
[[Category: B-sheet hydrophobic core]]
[[Category: B-sheet hydrophobic core]]
[[Category: Calcium]]
[[Category: Calcium]]
Line 45: Line 57:
[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zymogen]]
[[Category: Zymogen]]
- 
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:28:00 2008''
 

Current revision

Solution structure of the hemopexin-like domain of MMP12

PDB ID 2jxy

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jxy"
Personal tools