2i88

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{{Seed}}
 
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[[Image:2i88.png|left|200px]]
 
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==Crystal structure of the Channel-forming Domain of Colicin E1==
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The line below this paragraph, containing "STRUCTURE_2i88", creates the "Structure Box" on the page.
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<StructureSection load='2i88' size='340' side='right'caption='[[2i88]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2i88]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I88 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i88 OCA], [https://pdbe.org/2i88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i88 RCSB], [https://www.ebi.ac.uk/pdbsum/2i88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i88 ProSAT]</span></td></tr>
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{{STRUCTURE_2i88| PDB=2i88 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CEA1_ECOLX CEA1_ECOLX] This colicin is a channel-forming colicin. This class of transmembrane toxins depolarize the cytoplasmic membrane, leading to dissipation of cellular energy. Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i8/2i88_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i88 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the Channel-forming Domain of Colicin E1===
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==See Also==
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*[[Colicin 3D structures|Colicin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9083117}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9083117 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9083117}}
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==About this Structure==
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2I88 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I88 OCA].
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==Reference==
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A mechanism for toxin insertion into membranes is suggested by the crystal structure of the channel-forming domain of colicin E1., Elkins P, Bunker A, Cramer WA, Stauffacher CV, Structure. 1997 Mar 15;5(3):443-58. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9083117 9083117]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bunker, A]]
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[[Category: Bunker A]]
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[[Category: Cramer, W A.]]
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[[Category: Cramer WA]]
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[[Category: Elkins, P.]]
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[[Category: Elkins P]]
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[[Category: Stauffacher, C V.]]
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[[Category: Stauffacher CV]]
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[[Category: Colicin]]
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[[Category: Protein-membrane interaction]]
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[[Category: Toxin structure]]
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[[Category: Toxin-membrane interaction]]
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[[Category: Voltage-gated channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:57:02 2008''
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Current revision

Crystal structure of the Channel-forming Domain of Colicin E1

PDB ID 2i88

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