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1wxr

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{{Seed}}
 
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[[Image:1wxr.png|left|200px]]
 
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<!--
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==Crystal structure of Heme Binding protein, an autotransporter hemoglobine protease from pathogenic Escherichia coli==
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The line below this paragraph, containing "STRUCTURE_1wxr", creates the "Structure Box" on the page.
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<StructureSection load='1wxr' size='340' side='right'caption='[[1wxr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wxr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxr OCA], [https://pdbe.org/1wxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxr RCSB], [https://www.ebi.ac.uk/pdbsum/1wxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxr ProSAT]</span></td></tr>
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{{STRUCTURE_1wxr| PDB=1wxr | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of Heme Binding protein, an autotransporter hemoglobine protease from pathogenic Escherichia coli===
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[https://www.uniprot.org/uniprot/HBP_ECOLX HBP_ECOLX] Interacts with hemoglobin, degrades it and subsequently binds the released heme. Could make heme accessible not only for E.coli, but also for B.fragilis during mixed intra-abdominal infections. Has a role in abscess formation.<ref>PMID:9743528</ref> <ref>PMID:11748157</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_15728184}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 15728184 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wx/1wxr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_15728184}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wxr ConSurf].
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1WXR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXR OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli., Otto BR, Sijbrandi R, Luirink J, Oudega B, Heddle JG, Mizutani K, Park SY, Tame JR, J Biol Chem. 2005 Apr 29;280(17):17339-45. Epub 2005 Feb 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15728184 15728184]
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Heddle, J G.]]
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[[Category: Heddle JG]]
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[[Category: Luirink, J.]]
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[[Category: Luirink J]]
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[[Category: Mizutani, K.]]
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[[Category: Mizutani K]]
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[[Category: Otto, B R.]]
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[[Category: Otto BR]]
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[[Category: Oudega, B.]]
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[[Category: Oudega B]]
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[[Category: Park, S Y.]]
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[[Category: Park S-Y]]
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[[Category: Sijbrandi, R.]]
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[[Category: Sijbrandi R]]
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[[Category: Tame, J R.H.]]
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[[Category: Tame JRH]]
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[[Category: Autotransporter]]
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[[Category: Beta helix]]
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[[Category: Heme uptake]]
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[[Category: Hemoglobine protease]]
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[[Category: Spate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:04:11 2008''
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Current revision

Crystal structure of Heme Binding protein, an autotransporter hemoglobine protease from pathogenic Escherichia coli

PDB ID 1wxr

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