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3c1y

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{{Seed}}
 
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[[Image:3c1y.png|left|200px]]
 
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==Structure of bacterial DNA damage sensor protein with co-purified and co-crystallized ligand==
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The line below this paragraph, containing "STRUCTURE_3c1y", creates the "Structure Box" on the page.
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<StructureSection load='3c1y' size='340' side='right'caption='[[3c1y]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C1Y FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2BA:(2R,3R,3AS,5R,7AR,9R,10R,10AS,12R,14AR)-2,9-BIS(6-AMINO-9H-PURIN-9-YL)OCTAHYDRO-2H,7H-DIFURO[3,2-D 3,2-J][1,3,7,9,2,8]TETRAOXADIPHOSPHACYCLODODECINE-3,5,10,12-TETROL+5,12-DIOXIDE'>2BA</scene></td></tr>
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{{STRUCTURE_3c1y| PDB=3c1y | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c1y OCA], [https://pdbe.org/3c1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c1y RCSB], [https://www.ebi.ac.uk/pdbsum/3c1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c1y ProSAT]</span></td></tr>
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</table>
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===Structure of bacterial DNA damage sensor protein with co-purified and co-crystallized ligand===
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== Function ==
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[https://www.uniprot.org/uniprot/DISA_THEMA DISA_THEMA] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity).<ref>PMID:18439896</ref> Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. Does not convert GTP to c-di-GMP.<ref>PMID:18439896</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_18439896}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18439896 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/3c1y_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18439896}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3C1Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C1Y OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c1y ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates., Witte G, Hartung S, Buttner K, Hopfner KP, Mol Cell. 2008 Apr 25;30(2):167-78. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18439896 18439896]
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<references/>
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[[Category: Single protein]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Buttner, K.]]
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[[Category: Buttner K]]
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[[Category: Hartung, S.]]
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[[Category: Hartung S]]
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[[Category: Hopfner, K P.]]
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[[Category: Hopfner KP]]
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[[Category: Witte, G.]]
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[[Category: Witte G]]
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[[Category: Dna binding protein]]
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[[Category: Dna damage]]
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[[Category: Dna repair]]
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[[Category: Dna-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:04:55 2008''
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Current revision

Structure of bacterial DNA damage sensor protein with co-purified and co-crystallized ligand

PDB ID 3c1y

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