2qf5

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{{Seed}}
 
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[[Image:2qf5.png|left|200px]]
 
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==High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (monoclinic form)==
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The line below this paragraph, containing "STRUCTURE_2qf5", creates the "Structure Box" on the page.
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<StructureSection load='2qf5' size='340' side='right'caption='[[2qf5]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2qf5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QF5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qf5 OCA], [https://pdbe.org/2qf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qf5 RCSB], [https://www.ebi.ac.uk/pdbsum/2qf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qf5 ProSAT]</span></td></tr>
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{{STRUCTURE_2qf5| PDB=2qf5 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MREC_STRR6 MREC_STRR6] Involved in formation and maintenance of cell shape.[UniProtKB:Q01466]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qf/2qf5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qf5 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacterial cell shape is dictated by the cell wall, a plastic structure that must adapt to growth and division whilst retaining its function as a selectively permeable barrier. The modulation of cell wall structure is achieved by a variety of enzymatic functions, all of which must be spatially regulated in a precise manner. The membrane-spanning essential protein MreC has been identified as the central hub in this process, linking the bacterial cytoskeleton to a variety of cell wall-modifying enzymes. Additionally, MreC can form filaments, believed to run perpendicularly to the membrane. We present here the 1.2 A resolution crystal structure of the major periplasmic domain of Streptococcus pneumoniae MreC. The protein shows a novel arrangement of two barrel-shaped domains, one of which shows homology to a known protein oligomerization motif, with the other resembling a catalytic domain from a bacterial protease. We discuss the implications of these results for MreC function, and detail the structural features of the molecule that may be responsible for the binding of partner proteins.
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===High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (monoclinic form)===
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High-resolution structure of the major periplasmic domain from the cell shape-determining filament MreC.,Lovering AL, Strynadka NC J Mol Biol. 2007 Sep 28;372(4):1034-44. Epub 2007 Jul 26. PMID:17707860<ref>PMID:17707860</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17707860}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2qf5" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17707860 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17707860}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2QF5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QF5 OCA].
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[[Category: Streptococcus pneumoniae R6]]
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[[Category: Lovering AL]]
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==Reference==
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[[Category: Strynadka NCJ]]
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High-resolution structure of the major periplasmic domain from the cell shape-determining filament MreC., Lovering AL, Strynadka NC, J Mol Biol. 2007 Sep 28;372(4):1034-44. Epub 2007 Jul 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17707860 17707860]
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[[Category: Single protein]]
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[[Category: Streptococcus pneumoniae r6]]
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[[Category: Lovering, A L.]]
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[[Category: Strynadka, N C.J.]]
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[[Category: Filament a-lytic protease fold]]
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[[Category: Structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:09:03 2008''
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Current revision

High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (monoclinic form)

PDB ID 2qf5

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