1z0r

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{{Seed}}
 
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[[Image:1z0r.png|left|200px]]
 
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==Solution Structure of the N-terminal DNA Recognition Domain of the Bacillus subtilis Transcription-State Regulator AbrB==
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The line below this paragraph, containing "STRUCTURE_1z0r", creates the "Structure Box" on the page.
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<StructureSection load='1z0r' size='340' side='right'caption='[[1z0r]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z0r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ekt 1ekt]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z0R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z0r OCA], [https://pdbe.org/1z0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z0r RCSB], [https://www.ebi.ac.uk/pdbsum/1z0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z0r ProSAT]</span></td></tr>
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{{STRUCTURE_1z0r| PDB=1z0r | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ABRB_BACSU ABRB_BACSU] Ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. It controls the expression of genes spovG and tycA. AbrB binds to the tycA promoter region at two A- and T-rich sites, it may be the sole repressor of tycA transcription.<ref>PMID:2504584</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z0/1z0r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z0r ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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New relationships found in the process of updating the structural classification of proteins (SCOP) database resulted in the revision of the structure of the N-terminal, DNA-binding domain of the transition state regulator AbrB. The dimeric AbrB domain shares a common fold with the addiction antidote MazE and the subunit of uncharacterized protein MraZ implicated in cell division and cell envelope formation. It has a detectable sequence similarity to both MazE and MraZ thus providing an evolutionary link between the two proteins. The putative DNA-binding site of AbrB is found on the same face as the DNA-binding site of MazE and appears similar, both in structure and sequence, to the exposed conserved region of MraZ. This strongly suggests that MraZ also binds DNA and allows for a consensus model of DNA recognition by the members of this novel protein superfamily.
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===Solution Structure of the N-terminal DNA Recognition Domain of the Bacillus subtilis Transcription-State Regulator AbrB===
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Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins.,Bobay BG, Andreeva A, Mueller GA, Cavanagh J, Murzin AG FEBS Lett. 2005 Oct 24;579(25):5669-74. Epub 2005 Oct 4. PMID:16223496<ref>PMID:16223496</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16223496}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1z0r" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16223496 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16223496}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1Z0R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ekt 1ekt]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z0R OCA].
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==Reference==
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Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins., Bobay BG, Andreeva A, Mueller GA, Cavanagh J, Murzin AG, FEBS Lett. 2005 Oct 24;579(25):5669-74. Epub 2005 Oct 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16223496 16223496]
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[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Andreeva, A.]]
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[[Category: Andreeva A]]
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[[Category: Bobay, B G.]]
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[[Category: Bobay BG]]
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[[Category: Cavanagh, J.]]
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[[Category: Cavanagh J]]
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[[Category: Mueller, G A.]]
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[[Category: Mueller GA]]
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[[Category: Murzin, A G.]]
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[[Category: Murzin AG]]
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[[Category: N-terminal dna-binding domain]]
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[[Category: Scop database]]
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[[Category: Transition state regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:11:56 2008''
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Current revision

Solution Structure of the N-terminal DNA Recognition Domain of the Bacillus subtilis Transcription-State Regulator AbrB

PDB ID 1z0r

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