3c9j

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{{Seed}}
 
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[[Image:3c9j.png|left|200px]]
 
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==The Crystal structure of Transmembrane domain of M2 protein and Amantadine complex==
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The line below this paragraph, containing "STRUCTURE_3c9j", creates the "Structure Box" on the page.
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<StructureSection load='3c9j' size='340' side='right'caption='[[3c9j]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c9j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Hong_Kong/156/97(H5N1)) Influenza A virus (A/Hong Kong/156/97(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C9J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=308:(3S,5S,7S)-TRICYCLO[3.3.1.1~3,7~]DECAN-1-AMINE'>308</scene></td></tr>
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{{STRUCTURE_3c9j| PDB=3c9j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c9j OCA], [https://pdbe.org/3c9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c9j RCSB], [https://www.ebi.ac.uk/pdbsum/3c9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c9j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/M2_I97A1 M2_I97A1] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
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===The Crystal structure of Transmembrane domain of M2 protein and Amantadine complex===
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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*[[M2 protein|M2 protein]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 18235504 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Acharya R]]
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{{ABSTRACT_PUBMED_18235504}}
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[[Category: Salom D]]
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[[Category: Stouffer AL]]
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==About this Structure==
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3C9J is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C9J OCA].
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==Reference==
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Structural basis for the function and inhibition of an influenza virus proton channel., Stouffer AL, Acharya R, Salom D, Levine AS, Di Costanzo L, Soto CS, Tereshko V, Nanda V, Stayrook S, DeGrado WF, Nature. 2008 Jan 31;451(7178):596-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18235504 18235504]
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[[Category: Single protein]]
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[[Category: Acharya, R.]]
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[[Category: Salom, D.]]
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[[Category: Stouffer, A L.]]
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[[Category: Ion channel]]
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[[Category: M2-amantadine complex]]
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[[Category: M2tm]]
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[[Category: Membrane protein]]
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[[Category: Proton channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:14:05 2008''
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Current revision

The Crystal structure of Transmembrane domain of M2 protein and Amantadine complex

PDB ID 3c9j

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