2f9a

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{{Seed}}
 
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[[Image:2f9a.png|left|200px]]
 
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==HMG-CoA synthase from Brassica juncea in complex with F-244==
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The line below this paragraph, containing "STRUCTURE_2f9a", creates the "Structure Box" on the page.
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<StructureSection load='2f9a' size='340' side='right'caption='[[2f9a]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brassica_juncea Brassica juncea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F9A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F24:(7R,12R,13R)-13-FORMYL-12,14-DIHYDROXY-3,5,7-TRIMETHYLTETRADECA-2,4-DIENOIC+ACID'>F24</scene></td></tr>
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{{STRUCTURE_2f9a| PDB=2f9a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f9a OCA], [https://pdbe.org/2f9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f9a RCSB], [https://www.ebi.ac.uk/pdbsum/2f9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f9a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9M6U3_BRAJU Q9M6U3_BRAJU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/2f9a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f9a ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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3-Hydroxy-3-methylglutaryl CoA synthase (HMGS) catalyzes the first committed step in the mevalonate metabolic pathway for isoprenoid biosynthesis and serves as an alternative target for cholesterol-lowering and antibiotic drugs. We have determined a previously undescribed crystal structure of a eukaryotic HMGS bound covalently to a potent and specific inhibitor F-244 [(E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecad ienenoic acid]. Given the accessibility of synthetic analogs of the F-244 natural product, this inhibited eukaryotic HMGS structure serves as a necessary starting point for structure-based methods that may improve the potency and species-specific selectivity of the next generation of F-244 analogs designed to target particular eukaryotic and prokaryotic HMGS.
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===HMG-CoA synthase from Brassica juncea in complex with F-244===
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Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.,Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel JP Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11491-6. Epub 2006 Jul 24. PMID:16864776<ref>PMID:16864776</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16864776}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2f9a" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16864776 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16864776}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2F9A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Brassica_juncea Brassica juncea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9A OCA].
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==Reference==
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Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases., Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel JP, Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11491-6. Epub 2006 Jul 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16864776 16864776]
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[[Category: Brassica juncea]]
[[Category: Brassica juncea]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ferrer, J L.]]
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[[Category: Ferrer JL]]
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[[Category: Noel, J P.]]
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[[Category: Noel JP]]
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[[Category: Pojer, F.]]
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[[Category: Pojer F]]
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[[Category: Richard, S B.]]
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[[Category: Richard SB]]
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[[Category: F-244]]
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[[Category: Hmgs1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:14:42 2008''
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Current revision

HMG-CoA synthase from Brassica juncea in complex with F-244

PDB ID 2f9a

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