2id0

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{{Seed}}
 
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[[Image:2id0.png|left|200px]]
 
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==Escherichia coli RNase II==
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The line below this paragraph, containing "STRUCTURE_2id0", creates the "Structure Box" on the page.
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<StructureSection load='2id0' size='340' side='right'caption='[[2id0]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2id0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ID0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ID0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2id0| PDB=2id0 | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rnb ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Exoribonuclease_II Exoribonuclease II], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.1 3.1.13.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2id0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2id0 OCA], [https://pdbe.org/2id0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2id0 RCSB], [https://www.ebi.ac.uk/pdbsum/2id0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2id0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/RNB_ECOLI RNB_ECOLI]] Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.<ref>PMID:11948193</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/2id0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2id0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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RNase II is a member of the widely distributed RNR family of exoribonucleases, which are highly processive 3'--&gt;5' hydrolytic enzymes that play an important role in mRNA decay. Here, we report the crystal structure of E. coli RNase II, which reveals an architecture reminiscent of the RNA exosome. Three RNA-binding domains come together to form a clamp-like assembly, which can only accommodate single-stranded RNA. This leads into a narrow, basic channel that ends at the putative catalytic center that is completely enclosed within the body of the protein. The putative path for RNA agrees well with biochemical data indicating that a 3' single strand overhang of 7-10 nt is necessary for binding and hydrolysis by RNase II. The presence of the clamp and the narrow channel provides an explanation for the processivity of RNase II and for why its action is limited to single-stranded RNA.
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===Escherichia coli RNase II===
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Structural basis for processivity and single-strand specificity of RNase II.,Zuo Y, Vincent HA, Zhang J, Wang Y, Deutscher MP, Malhotra A Mol Cell. 2006 Oct 6;24(1):149-56. Epub 2006 Sep 21. PMID:16996291<ref>PMID:16996291</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2id0" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16996291}}, adds the Publication Abstract to the page
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16996291 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16996291}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Ecoli]]
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2ID0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ID0 OCA].
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==Reference==
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Structural basis for processivity and single-strand specificity of RNase II., Zuo Y, Vincent HA, Zhang J, Wang Y, Deutscher MP, Malhotra A, Mol Cell. 2006 Oct 6;24(1):149-56. Epub 2006 Sep 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16996291 16996291]
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[[Category: Escherichia coli]]
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[[Category: Exoribonuclease II]]
[[Category: Exoribonuclease II]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Malhotra, A.]]
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[[Category: Malhotra, A]]
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[[Category: Wang, Y.]]
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[[Category: Wang, Y]]
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[[Category: Zhang, J.]]
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[[Category: Zhang, J]]
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[[Category: Zuo, Y.]]
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[[Category: Zuo, Y]]
[[Category: Exonuclease]]
[[Category: Exonuclease]]
[[Category: Exoribonuclease]]
[[Category: Exoribonuclease]]
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[[Category: Hydrolase]]
[[Category: Hydrolyase]]
[[Category: Hydrolyase]]
[[Category: Mrna decay]]
[[Category: Mrna decay]]
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[[Category: Rnase]]
[[Category: Rnase]]
[[Category: Rnr family]]
[[Category: Rnr family]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:24:08 2008''
 

Current revision

Escherichia coli RNase II

PDB ID 2id0

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