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1syq

From Proteopedia

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{{Seed}}
 
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[[Image:1syq.png|left|200px]]
 
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==Human vinculin head domain VH1, residues 1-258, in complex with human talin's vinculin binding site 1, residues 607-636==
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The line below this paragraph, containing "STRUCTURE_1syq", creates the "Structure Box" on the page.
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<StructureSection load='1syq' size='340' side='right'caption='[[1syq]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1syq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SYQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1syq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1syq OCA], [https://pdbe.org/1syq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1syq RCSB], [https://www.ebi.ac.uk/pdbsum/1syq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1syq ProSAT]</span></td></tr>
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{{STRUCTURE_1syq| PDB=1syq | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/VINC_HUMAN VINC_HUMAN] Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) [MIM:[https://omim.org/entry/611407 611407]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:11815424</ref> <ref>PMID:16236538</ref> Defects in VCL are the cause of familial hypertrophic cardiomyopathy type 15 (CMH15) [MIM:[https://omim.org/entry/613255 613255]. It is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:16712796</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/VINC_HUMAN VINC_HUMAN] Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.<ref>PMID:20484056</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sy/1syq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1syq ConSurf].
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<div style="clear:both"></div>
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===Human vinculin head domain VH1, residues 1-258, in complex with humantalin's vinculin binding site 1, residues 607-636===
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==See Also==
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*[[Talin 3D structures|Talin 3D structures]]
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*[[Vinculin|Vinculin]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_15070891}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 15070891 is the PubMed ID number.
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__TOC__
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-->
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</StructureSection>
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{{ABSTRACT_PUBMED_15070891}}
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==About this Structure==
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1SYQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SYQ OCA].
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==Reference==
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Structural basis for amplifying vinculin activation by talin., Izard T, Vonrhein C, J Biol Chem. 2004 Jun 25;279(26):27667-78. Epub 2004 Apr 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15070891 15070891]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Izard, T.]]
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[[Category: Izard T]]
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[[Category: Vonrhein, C.]]
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[[Category: Vonrhein C]]
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[[Category: Cytoskeleton]]
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[[Category: Talin]]
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[[Category: Vinculin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:25:27 2008''
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Current revision

Human vinculin head domain VH1, residues 1-258, in complex with human talin's vinculin binding site 1, residues 607-636

PDB ID 1syq

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