1pn5

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{{Seed}}
 
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[[Image:1pn5.png|left|200px]]
 
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==NMR structure of the NALP1 Pyrin domain (PYD)==
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The line below this paragraph, containing "STRUCTURE_1pn5", creates the "Structure Box" on the page.
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<StructureSection load='1pn5' size='340' side='right'caption='[[1pn5]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pn5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PN5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pn5 OCA], [https://pdbe.org/1pn5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pn5 RCSB], [https://www.ebi.ac.uk/pdbsum/1pn5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pn5 ProSAT]</span></td></tr>
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{{STRUCTURE_1pn5| PDB=1pn5 | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NLRP1_HUMAN NLRP1_HUMAN] Vitiligo-associated autoimmune disease;Vitiligo;Corneal intraepithelial dyskeratosis with palmoplantar hyperkeratosis and laryngeal dyskeratosis. Disease susceptibility is associated with variations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/SPG1_STRSG SPG1_STRSG] Binds to the constant Fc region of IgG with high affinity.[https://www.uniprot.org/uniprot/NLRP1_HUMAN NLRP1_HUMAN] As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). Binds ATP (PubMed:11113115, PubMed:15212762).[UniProtKB:A1Z198]<ref>PMID:11113115</ref> <ref>PMID:15212762</ref> <ref>PMID:17349957</ref> <ref>PMID:17418785</ref> <ref>PMID:18511561</ref> <ref>PMID:19651869</ref> <ref>PMID:22665479</ref> <ref>PMID:27662089</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/1pn5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pn5 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Signaling in apoptosis and inflammation is often mediated by proteins of the death domain superfamily in the Fas/FADD/Caspase-8 or the Apaf-1/Caspase-9 pathways. This superfamily currently comprises the death domain (DD), death effector domain (DED), caspase recruitment domain (CARD), and pyrin domain (PYD) subfamilies. The PYD subfamily is most abundant, but three-dimensional structures are only available for the subfamilies DD, DED, and CARD, which have an antiparallel arrangement of six alpha helices as common fold. This paper presents the NMR structure of PYD of NALP1, a protein that is involved in the innate immune response and is a component of the inflammasome. The structure of NALP1 PYD differs from all other known death domain superfamily structures in that the third alpha helix is replaced by a flexibly disordered loop. This unique feature appears to relate to the molecular basis of familial Mediterranean fever (FMF), a genetic disease caused by single-point mutations.
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===NMR structure of the NALP1 Pyrin domain (PYD)===
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NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain.,Hiller S, Kohl A, Fiorito F, Herrmann T, Wider G, Tschopp J, Grutter MG, Wuthrich K Structure. 2003 Oct;11(10):1199-205. PMID:14527388<ref>PMID:14527388</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1pn5" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_14527388}}, adds the Publication Abstract to the page
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*[[Pyrin domain|Pyrin domain]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14527388 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14527388}}
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__TOC__
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</StructureSection>
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==Disease==
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Known disease associated with this structure: Vitiligo-associated multiple autoimmune disease susceptibility 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606636 606636]]
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==About this Structure==
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1PN5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN5 OCA].
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==Reference==
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NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain., Hiller S, Kohl A, Fiorito F, Herrmann T, Wider G, Tschopp J, Grutter MG, Wuthrich K, Structure. 2003 Oct;11(10):1199-205. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14527388 14527388]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Fiorito, F.]]
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[[Category: Fiorito F]]
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[[Category: Grutter, M G.]]
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[[Category: Grutter MG]]
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[[Category: Herrmann, T.]]
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[[Category: Herrmann T]]
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[[Category: Hiller, S.]]
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[[Category: Hiller S]]
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[[Category: Kohl, A.]]
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[[Category: Kohl A]]
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[[Category: Tschopp, J.]]
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[[Category: Tschopp J]]
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[[Category: Wider, G.]]
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[[Category: Wider G]]
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[[Category: Wuthrich, K.]]
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[[Category: Wuthrich K]]
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[[Category: 5 alpha-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:48:08 2008''
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Current revision

NMR structure of the NALP1 Pyrin domain (PYD)

PDB ID 1pn5

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