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2aru

From Proteopedia

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{{Seed}}
 
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[[Image:2aru.png|left|200px]]
 
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==Crystal structure of lipoate-protein ligase A bound with ATP==
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The line below this paragraph, containing "STRUCTURE_2aru", creates the "Structure Box" on the page.
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<StructureSection load='2aru' size='340' side='right'caption='[[2aru]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2aru]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ARU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2aru| PDB=2aru | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aru OCA], [https://pdbe.org/2aru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aru RCSB], [https://www.ebi.ac.uk/pdbsum/2aru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aru ProSAT]</span></td></tr>
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</table>
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===Crystal structure of lipoate-protein ligase A bound with ATP===
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== Function ==
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[https://www.uniprot.org/uniprot/LPLAN_THEAC LPLAN_THEAC] Part of a lipoate-protein ligase complex that catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Can also use octanoate as substrate.<ref>PMID:16141198</ref> <ref>PMID:19520844</ref> <ref>PMID:19594830</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16141198}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16141198 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ar/2aru_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16141198}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2ARU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARU OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aru ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure of lipoate-protein ligase A bound with the activated intermediate: insights into interaction with lipoyl domains., Kim DJ, Kim KH, Lee HH, Lee SJ, Ha JY, Yoon HJ, Suh SW, J Biol Chem. 2005 Nov 11;280(45):38081-9. Epub 2005 Sep 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16141198 16141198]
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<references/>
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[[Category: Single protein]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermoplasma acidophilum]]
[[Category: Thermoplasma acidophilum]]
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[[Category: Ha, J Y.]]
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[[Category: Ha JY]]
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[[Category: Kim, D J.]]
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[[Category: Kim DJ]]
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[[Category: Kim, K H.]]
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[[Category: Kim KH]]
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[[Category: Lee, H H.]]
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[[Category: Lee HH]]
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[[Category: Lee, S J.]]
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[[Category: Lee SJ]]
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[[Category: Suh, S W.]]
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[[Category: Suh SW]]
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[[Category: Yoon, H J.]]
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[[Category: Yoon HJ]]
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[[Category: Ligase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:53:00 2008''
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Current revision

Crystal structure of lipoate-protein ligase A bound with ATP

PDB ID 2aru

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