1ni1

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{{Seed}}
 
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[[Image:1ni1.png|left|200px]]
 
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==Imidazole and cyanophenyl farnesyl transferase inhibitors==
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The line below this paragraph, containing "STRUCTURE_1ni1", creates the "Structure Box" on the page.
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<StructureSection load='1ni1' size='340' side='right'caption='[[1ni1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ni1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NI1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2C5:2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)-+METHOXYMETHYL]-NICOTINONITRILE'>2C5</scene>, <scene name='pdbligand=HFP:ALPHA-HYDROXYFARNESYLPHOSPHONIC+ACID'>HFP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1ni1| PDB=1ni1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ni1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ni1 OCA], [https://pdbe.org/1ni1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ni1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ni1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ni1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ni/1ni1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ni1 ConSurf].
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<div style="clear:both"></div>
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===Imidazole and cyanophenyl farnesyl transferase inhibitors===
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==See Also==
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*[[Farnesyltransferase 3D structures|Farnesyltransferase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12699757}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12699757 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12699757}}
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==About this Structure==
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1NI1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NI1 OCA].
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==Reference==
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Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability., Tong Y, Lin NH, Wang L, Hasvold L, Wang W, Leonard N, Li T, Li Q, Cohen J, Gu WZ, Zhang H, Stoll V, Bauch J, Marsh K, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2003 May 5;13(9):1571-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12699757 12699757]
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[[Category: Protein complex]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Bauch, J.]]
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[[Category: Bauch J]]
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[[Category: Cohen, J.]]
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[[Category: Cohen J]]
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[[Category: Gu, W Z.]]
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[[Category: Gu WZ]]
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[[Category: Hasvold, L.]]
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[[Category: Hasvold L]]
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[[Category: Leonard, N.]]
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[[Category: Leonard N]]
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[[Category: Li, Q.]]
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[[Category: Li Q]]
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[[Category: Li, T.]]
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[[Category: Li T]]
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[[Category: Lin, N H.]]
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[[Category: Lin NH]]
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[[Category: Marsh, K.]]
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[[Category: Marsh K]]
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[[Category: Rosenberg, S H.]]
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[[Category: Rosenberg SH]]
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[[Category: Sham, H L.]]
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[[Category: Sham HL]]
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[[Category: Stoll, V.]]
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[[Category: Stoll V]]
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[[Category: Tong, Y.]]
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[[Category: Tong Y]]
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[[Category: Wang, L.]]
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[[Category: Wang L]]
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[[Category: Wang, W.]]
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[[Category: Wang W]]
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[[Category: Zhang, H.]]
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[[Category: Zhang H]]
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[[Category: Cyanophenyl]]
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[[Category: Ftase]]
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[[Category: Prenyltransferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:57:08 2008''
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Current revision

Imidazole and cyanophenyl farnesyl transferase inhibitors

PDB ID 1ni1

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