2a2p

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{{Seed}}
 
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[[Image:2a2p.png|left|200px]]
 
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==Solution structure of SelM from Mus musculus==
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The line below this paragraph, containing "STRUCTURE_2a2p", creates the "Structure Box" on the page.
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<StructureSection load='2a2p' size='340' side='right'caption='[[2a2p]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2a2p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A2P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2p OCA], [https://pdbe.org/2a2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a2p RCSB], [https://www.ebi.ac.uk/pdbsum/2a2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a2p ProSAT]</span></td></tr>
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{{STRUCTURE_2a2p| PDB=2a2p | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SELM_MOUSE SELM_MOUSE] May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a2/2a2p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a2p ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Selenium has significant health benefits, including potent cancer prevention activity and roles in immune function and the male reproductive system. Selenium-containing proteins, which incorporate this essential micronutrient as selenocysteine, are proposed to mediate the positive effects of dietary selenium. Presented here are the solution NMR structures of the selenoprotein SelM and an ortholog of the selenoprotein Sep15. These data reveal that Sep15 and SelM are structural homologs that establish a new thioredoxin-like protein family. The location of the active-site redox motifs within the fold together with the observed localized conformational changes after thiol-disulfide exchange and measured redox potential indicate that they have redox activity. In mammals, Sep15 expression is regulated by dietary selenium, and either decreased or increased expression of this selenoprotein alters redox homeostasis. A physiological role for Sep15 and SelM as thiol-disulfide oxidoreductases and their contribution to the quality control pathways of the endoplasmic reticulum are discussed.
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===Solution structure of SelM from Mus musculus===
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NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.,Ferguson AD, Labunskyy VM, Fomenko DE, Arac D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J J Biol Chem. 2006 Feb 10;281(6):3536-43. Epub 2005 Nov 30. PMID:16319061<ref>PMID:16319061</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16319061}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2a2p" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16319061 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16319061}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2A2P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2P OCA].
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==Reference==
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NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family., Ferguson AD, Labunskyy VM, Fomenko DE, Arac D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J, J Biol Chem. 2006 Feb 10;281(6):3536-43. Epub 2005 Nov 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16319061 16319061]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Amezcua CA]]
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[[Category: Amezcua, C A.]]
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[[Category: Chelliah Y]]
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[[Category: Chelliah, Y.]]
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[[Category: Deisenhofer J]]
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[[Category: Deisenhofer, J.]]
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[[Category: Ferguson AD]]
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[[Category: Ferguson, A D.]]
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[[Category: Fomenko DE]]
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[[Category: Fomenko, D E.]]
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[[Category: Gladyshev VN]]
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[[Category: Gladyshev, V N.]]
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[[Category: Labunskyy VM]]
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[[Category: Labunskyy, V M.]]
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[[Category: Rizo J]]
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[[Category: Rizo, J.]]
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[[Category: Redox enzyme]]
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[[Category: Selenoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:17:51 2008''
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Current revision

Solution structure of SelM from Mus musculus

PDB ID 2a2p

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