3gbp

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(New page: 200px<br /><applet load="3gbp" size="450" color="white" frame="true" align="right" spinBox="true" caption="3gbp, resolution 2.4&Aring;" /> '''STRUCTURE OF THE PERI...)
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[[Image:3gbp.gif|left|200px]]<br /><applet load="3gbp" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="3gbp, resolution 2.4&Aring;" />
 
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'''STRUCTURE OF THE PERIPLASMIC GLUCOSE/GALACTOSE RECEPTOR OF SALMONELLA TYPHIMURIUM'''<br />
 
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==Overview==
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==STRUCTURE OF THE PERIPLASMIC GLUCOSE/GALACTOSE RECEPTOR OF SALMONELLA TYPHIMURIUM==
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The X-ray structure of the periplasmic glucose/galactose receptor (binding, protein) of Salmonella typhimurium has been solved by the method of, multiple isomorphous replacement and refined to a resolution of 2.4 A with, an R-factor of 15.8%. The protein consists of two highly-similar, structural domains with a bound sugar molecule trapped between. A combined, sequence/structural approach is used to compare the structure of this, protein to a similar arabinose receptor. The new sequence alignment, obtained is used to analyze a number of features conserved for structural, and functional reasons. This information allowed the prediction of similar, features within the sequence of the analogous ribose receptor. Some of the, consequences of the structures for chemotaxis and transport are discussed.
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<StructureSection load='3gbp' size='340' side='right'caption='[[3gbp]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3gbp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gbp 1gbp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GBP FirstGlance]. <br>
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3GBP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium] with GLC and CA as [http://en.wikipedia.org/wiki/ligands ligands]. This structure superseeds the now removed PDB entry 1GBP. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3GBP OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbp OCA], [https://pdbe.org/3gbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gbp RCSB], [https://www.ebi.ac.uk/pdbsum/3gbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbp ProSAT]</span></td></tr>
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Structure of the periplasmic glucose/galactose receptor of Salmonella typhimurium., Mowbray SL, Smith RD, Cole LB, Receptor. 1990-1991 Winter;1(1-2):41-53. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1967096 1967096]
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</table>
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[[Category: Salmonella typhimurium]]
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== Function ==
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[[Category: Single protein]]
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[https://www.uniprot.org/uniprot/MGLB_SALTY MGLB_SALTY] Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import (By similarity). In addition, binds D-galactose and D-glucose and plays a role in the chemotaxis towards these two sugars by interacting with the Trg chemoreceptor (Probable).[UniProtKB:P0AEE5]<ref>PMID:8132630</ref> <ref>PMID:8240551</ref>
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[[Category: Mowbray, S.L.]]
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== Evolutionary Conservation ==
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[[Category: CA]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: GLC]]
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Check<jmol>
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[[Category: periplasmic binding protein]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbp_consurf.spt"</scriptWhenChecked>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 19:44:14 2007''
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gbp ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Mowbray SL]]

Current revision

STRUCTURE OF THE PERIPLASMIC GLUCOSE/GALACTOSE RECEPTOR OF SALMONELLA TYPHIMURIUM

PDB ID 3gbp

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