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2p9u

From Proteopedia

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{{Seed}}
 
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[[Image:2p9u.png|left|200px]]
 
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==Crystal structure of bovine Arp2/3 complex co-crystallized with AMP-PNP and calcium==
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The line below this paragraph, containing "STRUCTURE_2p9u", creates the "Structure Box" on the page.
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<StructureSection load='2p9u' size='340' side='right'caption='[[2p9u]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2p9u]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P9U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_2p9u| PDB=2p9u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p9u OCA], [https://pdbe.org/2p9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p9u RCSB], [https://www.ebi.ac.uk/pdbsum/2p9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p9u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARP3_BOVIN ARP3_BOVIN] Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p9/2p9u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p9u ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of bovine Arp2/3 complex co-crystallized with AMP-PNP and calcium===
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==See Also==
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*[[Actin-related protein 3D structures|Actin-related protein 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_17499050}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17499050 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17499050}}
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==About this Structure==
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2P9U is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P9U OCA].
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==Reference==
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Insights into the influence of nucleotides on actin family proteins from seven structures of Arp2/3 complex., Nolen BJ, Pollard TD, Mol Cell. 2007 May 11;26(3):449-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17499050 17499050]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Nolen, B J.]]
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[[Category: Nolen BJ]]
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[[Category: Pollard, T D.]]
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[[Category: Pollard TD]]
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[[Category: Actin]]
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[[Category: Complex]]
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[[Category: Wd repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:37:03 2008''
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Current revision

Crystal structure of bovine Arp2/3 complex co-crystallized with AMP-PNP and calcium

PDB ID 2p9u

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