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1tfa

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{{Seed}}
 
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[[Image:1tfa.png|left|200px]]
 
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==OVOTRANSFERRIN, N-TERMINAL LOBE, APO FORM==
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The line below this paragraph, containing "STRUCTURE_1tfa", creates the "Structure Box" on the page.
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<StructureSection load='1tfa' size='340' side='right'caption='[[1tfa]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tfa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TFA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1tfa| PDB=1tfa | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tfa OCA], [https://pdbe.org/1tfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tfa RCSB], [https://www.ebi.ac.uk/pdbsum/1tfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tfa ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRFE_CHICK TRFE_CHICK] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. There are two forms of hen transferrin, ovotransferrin, found in the ovoducts and, serum transferrin, secreted by the liver. Serum transferrin may also have a role in stimulating cell proliferation and is regulated by iron levels. Ovotransferrin has a bacteriostatic function and, is not controlled by iron levels.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tf/1tfa_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tfa ConSurf].
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<div style="clear:both"></div>
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===OVOTRANSFERRIN, N-TERMINAL LOBE, APO FORM===
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==See Also==
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*[[Transferrin 3D structures|Transferrin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10187803}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10187803 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10187803}}
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==About this Structure==
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1TFA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFA OCA].
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==Reference==
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Alternative structural state of transferrin. The crystallographic analysis of iron-loaded but domain-opened ovotransferrin N-lobe., Mizutani K, Yamashita H, Kurokawa H, Mikami B, Hirose M, J Biol Chem. 1999 Apr 9;274(15):10190-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10187803 10187803]
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hirose, M.]]
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[[Category: Hirose M]]
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[[Category: Mikami, B.]]
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[[Category: Mikami B]]
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[[Category: Mizutani, K.]]
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[[Category: Mizutani K]]
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[[Category: Yamashita, H.]]
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[[Category: Yamashita H]]
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[[Category: Iron binding protein]]
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[[Category: Ovotransferrin]]
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[[Category: Transferrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:41:45 2008''
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Current revision

OVOTRANSFERRIN, N-TERMINAL LOBE, APO FORM

PDB ID 1tfa

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