2hs6

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{{Seed}}
 
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[[Image:2hs6.png|left|200px]]
 
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==Crystal structure of the E291K mutant of 12-oxophytodienoate reductase 3 (OPR3) from tomato==
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The line below this paragraph, containing "STRUCTURE_2hs6", creates the "Structure Box" on the page.
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<StructureSection load='2hs6' size='340' side='right'caption='[[2hs6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hs6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Solanum_lycopersicum Solanum lycopersicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HS6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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{{STRUCTURE_2hs6| PDB=2hs6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hs6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hs6 OCA], [https://pdbe.org/2hs6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hs6 RCSB], [https://www.ebi.ac.uk/pdbsum/2hs6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hs6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OPR3_SOLLC OPR3_SOLLC] Specifically cleaves olefinic bonds in cyclic enones. Involved in the biosynthesis of jasmonic acid (JA) and perhaps in biosynthesis or metabolism of other oxylipin signaling moleclules. It is required for the spatial and temporal regulation of JA levels during dehiscence of anthers, promoting the stomium degeneration program (By similarity). In vitro, reduces 9S,13S-12-oxophytodienoic acid (9S,13S-OPDA) and 9R,13R-OPDA to 9S,13S-OPC-8:0 and 9R,13R-OPC-8:0, respectively.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/2hs6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hs6 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the E291K mutant of 12-oxophytodienoate reductase 3 (OPR3) from tomato===
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==See Also==
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*[[12-oxophytodienoate reductase 3D structures|12-oxophytodienoate reductase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16983071}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16983071 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16983071}}
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==About this Structure==
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2HS6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Solanum_lycopersicum Solanum lycopersicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HS6 OCA].
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==Reference==
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Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization., Breithaupt C, Kurzbauer R, Lilie H, Schaller A, Strassner J, Huber R, Macheroux P, Clausen T, Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14337-42. Epub 2006 Sep 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16983071 16983071]
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[[Category: 12-oxophytodienoate reductase]]
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[[Category: Single protein]]
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[[Category: Solanum lycopersicum]]
[[Category: Solanum lycopersicum]]
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[[Category: Breithaupt, C.]]
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[[Category: Breithaupt C]]
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[[Category: Clausen, T.]]
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[[Category: Clausen T]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Alpha beta 8 barrel]]
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[[Category: Flavoprotein]]
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[[Category: Jasmonate biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:47:51 2008''
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Current revision

Crystal structure of the E291K mutant of 12-oxophytodienoate reductase 3 (OPR3) from tomato

PDB ID 2hs6

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