3icd

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(New page: 200px<br /><applet load="3icd" size="450" color="white" frame="true" align="right" spinBox="true" caption="3icd, resolution 2.5&Aring;" /> '''STRUCTURE OF A BACTER...)
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[[Image:3icd.jpg|left|200px]]<br /><applet load="3icd" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="3icd, resolution 2.5&Aring;" />
 
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'''STRUCTURE OF A BACTERIAL ENZYME REGULATED BY PHOSPHORYLATION, ISOCITRATE DEHYDROGENASE'''<br />
 
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==Overview==
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==STRUCTURE OF A BACTERIAL ENZYME REGULATED BY PHOSPHORYLATION, ISOCITRATE DEHYDROGENASE==
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The structure of isocitrate dehydrogenase [threo-DS-isocitrate: NADP+, oxidoreductase (decarboxylating), EC 1.1.1.42] from Escherichia coli has, been solved and refined at 2.5 A resolution and is topologically different, from that of any other dehydrogenase. This enzyme, a dimer of identical, 416-residue subunits, is inactivated by phosphorylation at Ser-113, which, lies at the edge of an interdomain pocket that also contains many residues, conserved between isocitrate dehydrogenase and isopropylmalate, dehydrogenase. Isocitrate dehydrogenase contains an unusual clasp-like, domain in which both polypeptide chains in the dimer interlock. Based on, the structure of isocitrate dehydrogenase and conservation with, isopropylmalate dehydrogenase, we suggest that the active site lies in an, interdomain pocket close to the phosphorylation site.
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<StructureSection load='3icd' size='340' side='right'caption='[[3icd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3icd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The September 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Isocitrate Dehydrogenase'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_9 10.2210/rcsb_pdb/mom_2010_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ICD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3icd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3icd OCA], [https://pdbe.org/3icd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3icd RCSB], [https://www.ebi.ac.uk/pdbsum/3icd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3icd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IDH_ECOLI IDH_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/3icd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3icd ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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3ICD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Active as [http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3ICD OCA].
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*[[Isocitrate dehydrogenase 3D structures|Isocitrate dehydrogenase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase., Hurley JH, Thorsness PE, Ramalingam V, Helmers NH, Koshland DE Jr, Stroud RM, Proc Natl Acad Sci U S A. 1989 Nov;86(22):8635-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2682654 2682654]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Isocitrate dehydrogenase (NADP(+))]]
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[[Category: Isocitrate Dehydrogenase]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Helmers, N.H.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Hurley, J.H.]]
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[[Category: Helmers NH]]
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[[Category: Koshlandjunior, D.E.]]
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[[Category: Hurley JH]]
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[[Category: Ramalingam, V.]]
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[[Category: Koshlandjunior DE]]
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[[Category: Stroud, R.M.]]
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[[Category: Ramalingam V]]
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[[Category: Thorsness, P.E.]]
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[[Category: Stroud RM]]
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[[Category: oxidoreductase (nad(a)-choh(d))]]
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[[Category: Thorsness PE]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 19:47:51 2007''
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Current revision

STRUCTURE OF A BACTERIAL ENZYME REGULATED BY PHOSPHORYLATION, ISOCITRATE DEHYDROGENASE

PDB ID 3icd

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