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1quh

From Proteopedia

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{{Seed}}
 
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[[Image:1quh.png|left|200px]]
 
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==L99G/E108V MUTANT OF T4 LYSOZYME==
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The line below this paragraph, containing "STRUCTURE_1quh", creates the "Structure Box" on the page.
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<StructureSection load='1quh' size='340' side='right'caption='[[1quh]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1quh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QUH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
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{{STRUCTURE_1quh| PDB=1quh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1quh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1quh OCA], [https://pdbe.org/1quh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1quh RCSB], [https://www.ebi.ac.uk/pdbsum/1quh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1quh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qu/1quh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1quh ConSurf].
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<div style="clear:both"></div>
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===L99G/E108V MUTANT OF T4 LYSOZYME===
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==See Also==
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_10512706}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10512706 is the PubMed ID number.
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</StructureSection>
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[[Category: Escherichia virus T4]]
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{{ABSTRACT_PUBMED_10512706}}
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[[Category: Large Structures]]
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[[Category: Baase WA]]
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==About this Structure==
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[[Category: Lindstrom JD]]
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1QUH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QUH OCA].
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[[Category: Matthews BW]]
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[[Category: Poteete AR]]
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==Reference==
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[[Category: Wray J]]
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Structural analysis of a non-contiguous second-site revertant in T4 lysozyme shows that increasing the rigidity of a protein can enhance its stability., Wray JW, Baase WA, Lindstrom JD, Weaver LH, Poteete AR, Matthews BW, J Mol Biol. 1999 Oct 8;292(5):1111-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10512706 10512706]
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[[Category: Enterobacteria phage t4]]
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[[Category: Lysozyme]]
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[[Category: Single protein]]
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[[Category: Baase, W A.]]
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[[Category: Lindstrom, J D.]]
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[[Category: Matthews, B W.]]
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[[Category: Poteete, A R]]
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[[Category: Wray, J.]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:41:47 2008''
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Current revision

L99G/E108V MUTANT OF T4 LYSOZYME

PDB ID 1quh

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