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1pue

From Proteopedia

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{{Seed}}
 
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[[Image:1pue.png|left|200px]]
 
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<!--
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==PU.1 ETS DOMAIN-DNA COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1pue", creates the "Structure Box" on the page.
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<StructureSection load='1pue' size='340' side='right'caption='[[1pue]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pue]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PUE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pue OCA], [https://pdbe.org/1pue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pue RCSB], [https://www.ebi.ac.uk/pdbsum/1pue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pue ProSAT]</span></td></tr>
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{{STRUCTURE_1pue| PDB=1pue | SCENE= }}
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</table>
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== Disease ==
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===PU.1 ETS DOMAIN-DNA COMPLEX===
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[https://www.uniprot.org/uniprot/SPI1_MOUSE SPI1_MOUSE] Note=Involved in murine acute Friend erythroleukemia. It is a target region for SFFV proviral insertion.
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== Function ==
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[https://www.uniprot.org/uniprot/SPI1_MOUSE SPI1_MOUSE] Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.<ref>PMID:8626664</ref>
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== Evolutionary Conservation ==
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The line below this paragraph, {{ABSTRACT_PUBMED_8602247}}, adds the Publication Abstract to the page
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 8602247 is the PubMed ID number.
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Check<jmol>
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<jmolCheckbox>
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{{ABSTRACT_PUBMED_8602247}}
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pu/1pue_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==About this Structure==
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<text>to colour the structure by Evolutionary Conservation</text>
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1PUE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PUE OCA].
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pue ConSurf].
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==Reference==
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<div style="clear:both"></div>
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A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex., Kodandapani R, Pio F, Ni CZ, Piccialli G, Klemsz M, McKercher S, Maki RA, Ely KR, Nature. 1996 Apr 4;380(6573):456-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8602247 8602247]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Synthetic construct]]
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[[Category: Ely, K. R.]]
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[[Category: Ely KR]]
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[[Category: Klemsz, M.]]
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[[Category: Klemsz M]]
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[[Category: Kodandapani, R.]]
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[[Category: Kodandapani R]]
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[[Category: Maki, R A.]]
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[[Category: Maki RA]]
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[[Category: McKercher, S.]]
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[[Category: McKercher S]]
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[[Category: Ni, C Z.]]
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[[Category: Ni CZ]]
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[[Category: Piccialli, G.]]
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[[Category: Piccialli G]]
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[[Category: Pio, F.]]
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[[Category: Pio F]]
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[[Category: Activator]]
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[[Category: Dna- binding]]
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[[Category: Nuclear protein]]
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[[Category: Oncogene]]
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[[Category: Transforming protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:47:00 2008''
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Current revision

PU.1 ETS DOMAIN-DNA COMPLEX

PDB ID 1pue

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