2hpo

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{{Seed}}
 
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[[Image:2hpo.png|left|200px]]
 
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==Structure of Aminopeptidase N from E. coli Suggests a Compartmentalized, Gated Active Site==
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The line below this paragraph, containing "STRUCTURE_2hpo", creates the "Structure Box" on the page.
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<StructureSection load='2hpo' size='340' side='right'caption='[[2hpo]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hpo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HPO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2hpo| PDB=2hpo | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hpo OCA], [https://pdbe.org/2hpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hpo RCSB], [https://www.ebi.ac.uk/pdbsum/2hpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hpo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMPN_ECOLI AMPN_ECOLI] Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/2hpo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hpo ConSurf].
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<div style="clear:both"></div>
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===Structure of Aminopeptidase N from E. coli Suggests a Compartmentalized, Gated Active Site===
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==See Also==
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16938892}}, adds the Publication Abstract to the page
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[[Category: Escherichia coli K-12]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16938892 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Addlagatta A]]
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{{ABSTRACT_PUBMED_16938892}}
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[[Category: Gay L]]
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[[Category: Matthews BW]]
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==About this Structure==
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2HPO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HPO OCA].
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==Reference==
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Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site., Addlagatta A, Gay L, Matthews BW, Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13339-44. Epub 2006 Aug 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16938892 16938892]
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[[Category: Escherichia coli]]
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[[Category: Membrane alanyl aminopeptidase]]
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[[Category: Single protein]]
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[[Category: Addlagatta, A.]]
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[[Category: Gay, L.]]
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[[Category: Matthews, B W.]]
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[[Category: Closed]]
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[[Category: Compartmentalized active site]]
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[[Category: Multidomain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:48:32 2008''
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Current revision

Structure of Aminopeptidase N from E. coli Suggests a Compartmentalized, Gated Active Site

PDB ID 2hpo

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