1t9r

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{{Seed}}
 
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[[Image:1t9r.png|left|200px]]
 
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==Catalytic Domain Of Human Phosphodiesterase 5A==
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The line below this paragraph, containing "STRUCTURE_1t9r", creates the "Structure Box" on the page.
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<StructureSection load='1t9r' size='340' side='right'caption='[[1t9r]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t9r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T9R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1t9r| PDB=1t9r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t9r OCA], [https://pdbe.org/1t9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t9r RCSB], [https://www.ebi.ac.uk/pdbsum/1t9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t9r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t9/1t9r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t9r ConSurf].
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<div style="clear:both"></div>
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===Catalytic Domain Of Human Phosphodiesterase 5A===
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15260978}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15260978 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15260978}}
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==About this Structure==
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1T9R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T9R OCA].
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==Reference==
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A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases., Zhang KY, Card GL, Suzuki Y, Artis DR, Fong D, Gillette S, Hsieh D, Neiman J, West BL, Zhang C, Milburn MV, Kim SH, Schlessinger J, Bollag G, Mol Cell. 2004 Jul 23;15(2):279-86. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15260978 15260978]
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Artis, D R.]]
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[[Category: Artis DR]]
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[[Category: Bollag, G.]]
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[[Category: Bollag G]]
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[[Category: Card, G L.]]
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[[Category: Card GL]]
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[[Category: Fong, D.]]
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[[Category: Fong D]]
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[[Category: Gillette, S.]]
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[[Category: Gillette S]]
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[[Category: Hsieh, D.]]
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[[Category: Hsieh D]]
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[[Category: Kim, S H.]]
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[[Category: Kim S-H]]
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[[Category: Milburn, M V.]]
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[[Category: Milburn MV]]
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[[Category: Neiman, J.]]
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[[Category: Neiman J]]
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[[Category: Schlessinger, J.]]
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[[Category: Schlessinger J]]
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[[Category: Suzuki, Y.]]
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[[Category: Suzuki Y]]
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[[Category: West, B L.]]
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[[Category: West BL]]
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[[Category: Zhang, C.]]
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[[Category: Zhang C]]
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[[Category: Zhang, K Y.J.]]
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[[Category: Zhang KYJ]]
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[[Category: Hydrolase]]
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[[Category: Pde5a]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:52:58 2008''
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Current revision

Catalytic Domain Of Human Phosphodiesterase 5A

PDB ID 1t9r

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