2uyz

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{{Seed}}
 
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[[Image:2uyz.png|left|200px]]
 
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==Non-covalent complex between Ubc9 and SUMO1==
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The line below this paragraph, containing "STRUCTURE_2uyz", creates the "Structure Box" on the page.
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<StructureSection load='2uyz' size='340' side='right'caption='[[2uyz]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2uyz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UYZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_2uyz| PDB=2uyz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uyz OCA], [https://pdbe.org/2uyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uyz RCSB], [https://www.ebi.ac.uk/pdbsum/2uyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uyz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UBC9_MOUSE UBC9_MOUSE] Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity).<ref>PMID:16326389</ref> <ref>PMID:17187077</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uy/2uyz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uyz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The ubiquitin-related modifier SUMO regulates a wide range of cellular processes by post-translational modification with one, or a chain of SUMO molecules. Sumoylation is achieved by the sequential action of several enzymes in which the E2, Ubc9, transfers SUMO from the E1 to the target mostly with the help of an E3 enzyme. In this process, Ubc9 not only forms a thioester bond with SUMO, but also interacts with SUMO noncovalently. Here, we show that this noncovalent interaction promotes the formation of short SUMO chains on targets such as Sp100 and HDAC4. We present a crystal structure of the noncovalent Ubc9-SUMO1 complex, showing that SUMO is located far from the E2 active site and resembles the noncovalent interaction site for ubiquitin on UbcH5c and Mms2. Structural comparison suggests a model for poly-sumoylation involving a mechanism analogous to Mms2-Ubc13-mediated ubiquitin chain formation.
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===NON-COVALENT COMPLEX BETWEEN UBC9 AND SUMO1===
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Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation.,Knipscheer P, van Dijk WJ, Olsen JV, Mann M, Sixma TK EMBO J. 2007 Jun 6;26(11):2797-807. Epub 2007 May 10. PMID:17491593<ref>PMID:17491593</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2uyz" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17491593}}, adds the Publication Abstract to the page
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*[[SUMO 3D Structures|SUMO 3D Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17491593 is the PubMed ID number.
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*[[SUMO conjugating enzyme Ubc9|SUMO conjugating enzyme Ubc9]]
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== References ==
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{{ABSTRACT_PUBMED_17491593}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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2UYZ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UYZ OCA].
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==Reference==
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Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation., Knipscheer P, van Dijk WJ, Olsen JV, Mann M, Sixma TK, EMBO J. 2007 Jun 6;26(11):2797-807. Epub 2007 May 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17491593 17491593]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Knipscheer P]]
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[[Category: Ubiquitin--protein ligase]]
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[[Category: Mann M]]
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[[Category: Dijk, W J.Van.]]
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[[Category: Olsen JV]]
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[[Category: Knipscheer, P.]]
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[[Category: Sixma TK]]
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[[Category: Mann, M.]]
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[[Category: Van Dijk WJ]]
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[[Category: Olsen, J V.]]
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[[Category: Sixma, T K.]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Chromosome partition]]
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[[Category: Conjugating enzyme]]
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[[Category: E2]]
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[[Category: Ligase]]
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[[Category: Mitosis]]
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[[Category: Nuclear protein]]
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[[Category: Sumo1]]
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[[Category: Sumoylation]]
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[[Category: Ubc9]]
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[[Category: Ubiquitin-like modifier]]
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[[Category: Ubl conjugation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:55:57 2008''
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Current revision

Non-covalent complex between Ubc9 and SUMO1

PDB ID 2uyz

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