1ktm

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(New page: 200px<br /><applet load="1ktm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ktm" /> '''SOLUTION STRUCTURE OF FAT DOMAIN OF FOCAL AD...)
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[[Image:1ktm.gif|left|200px]]<br /><applet load="1ktm" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ktm" />
 
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'''SOLUTION STRUCTURE OF FAT DOMAIN OF FOCAL ADHESION KINASE'''<br />
 
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==Overview==
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==SOLUTION STRUCTURE OF FAT DOMAIN OF FOCAL ADHESION KINASE==
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Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase whose focal, adhesion targeting (FAT) domain interacts with other focal adhesion, molecules in integrin-mediated signaling. Localization of activated FAK to, focal adhesions is indispensable for its function. Here we describe a, solution structure of the FAT domain bound to a peptide derived from, paxillin, a FAK-binding partner. The FAT domain is composed of four, helices that form a "right-turn" elongated bundle; the globular fold is, mainly maintained by hydrophobic interactions. The bound peptide further, stabilizes the structure. Certain signaling events such as phosphorylation, and molecule interplay may induce opening of the helix bundle. Such, conformational change is proposed to precede departure of FAK from focal, adhesions, which starts focal adhesion turnover.
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<StructureSection load='1ktm' size='340' side='right'caption='[[1ktm]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ktm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KTM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ktm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktm OCA], [https://pdbe.org/1ktm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ktm RCSB], [https://www.ebi.ac.uk/pdbsum/1ktm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ktm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FAK1_CHICK FAK1_CHICK] Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), ephrin receptors, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Regulates P53/TP53 activity and stability. Phosphorylates SRC; this increases SRC kinase activity. Isoform 2 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling.<ref>PMID:15494733</ref> <ref>PMID:15494734</ref> <ref>PMID:15494732</ref> <ref>PMID:20705914</ref> <ref>PMID:21852560</ref> <ref>PMID:21937583</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1ktm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ktm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase whose focal adhesion targeting (FAT) domain interacts with other focal adhesion molecules in integrin-mediated signaling. Localization of activated FAK to focal adhesions is indispensable for its function. Here we describe a solution structure of the FAT domain bound to a peptide derived from paxillin, a FAK-binding partner. The FAT domain is composed of four helices that form a "right-turn" elongated bundle; the globular fold is mainly maintained by hydrophobic interactions. The bound peptide further stabilizes the structure. Certain signaling events such as phosphorylation and molecule interplay may induce opening of the helix bundle. Such conformational change is proposed to precede departure of FAK from focal adhesions, which starts focal adhesion turnover.
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==About this Structure==
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Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase.,Liu G, Guibao CD, Zheng J Mol Cell Biol. 2002 Apr;22(8):2751-60. PMID:11909967<ref>PMID:11909967</ref>
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1KTM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KTM OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase., Liu G, Guibao CD, Zheng J, Mol Cell Biol. 2002 Apr;22(8):2751-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11909967 11909967]
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</div>
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[[Category: Gallus gallus]]
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<div class="pdbe-citations 1ktm" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Transferase]]
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[[Category: Guibao, C.]]
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[[Category: Liu, G.]]
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[[Category: Zheng, J.]]
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[[Category: fak]]
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[[Category: fat]]
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[[Category: focal adhension targeting domain]]
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[[Category: focal adhesion kinase]]
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[[Category: helix bundle]]
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[[Category: nmr]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 19:51:48 2007''
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==See Also==
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*[[Focal adhesion kinase 3D structures|Focal adhesion kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gallus gallus]]
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[[Category: Large Structures]]
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[[Category: Guibao C]]
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[[Category: Liu G]]
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[[Category: Zheng J]]

Current revision

SOLUTION STRUCTURE OF FAT DOMAIN OF FOCAL ADHESION KINASE

PDB ID 1ktm

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