1usk

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{{Seed}}
 
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[[Image:1usk.png|left|200px]]
 
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==L-leucine-binding protein with leucine bound==
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The line below this paragraph, containing "STRUCTURE_1usk", creates the "Structure Box" on the page.
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<StructureSection load='1usk' size='340' side='right'caption='[[1usk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1usk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1USK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1USK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr>
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{{STRUCTURE_1usk| PDB=1usk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1usk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1usk OCA], [https://pdbe.org/1usk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1usk RCSB], [https://www.ebi.ac.uk/pdbsum/1usk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1usk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LIVK_ECOLI LIVK_ECOLI] This protein is a component of the leucine-specific transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids in E.coli.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/us/1usk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1usk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The periplasmic leucine-binding protein is the primary receptor for the leucine transport system in Escherichia coli. We report here the structure of an open ligand-free form solved by molecular replacement and refined at 1.5-A resolution. In addition, two closed ligand-bound structures of the same protein are presented, a phenylalanine-bound form at 1.8 A and a leucine-bound structure at a nominal resolution of 2.4 A. These structures show the basis of this protein's ligand specificity, as well as illustrating the conformational changes that are associated with ligand binding. Comparison with earlier structures provides further information about solution conformations, as well as the different specificity of the closely related leucine/isoleucine/valine-binding protein.
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===L-LEUCINE-BINDING PROTEIN WITH LEUCINE BOUND===
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X-ray structures of the leucine-binding protein illustrate conformational changes and the basis of ligand specificity.,Magnusson U, Salopek-Sondi B, Luck LA, Mowbray SL J Biol Chem. 2004 Mar 5;279(10):8747-52. Epub 2003 Dec 12. PMID:14672931<ref>PMID:14672931</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_14672931}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1usk" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14672931 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14672931}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1USK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1USK OCA].
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==Reference==
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X-ray structures of the leucine-binding protein illustrate conformational changes and the basis of ligand specificity., Magnusson U, Salopek-Sondi B, Luck LA, Mowbray SL, J Biol Chem. 2004 Mar 5;279(10):8747-52. Epub 2003 Dec 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14672931 14672931]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Luck, L A.]]
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[[Category: Luck LA]]
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[[Category: Magnusson, U.]]
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[[Category: Magnusson U]]
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[[Category: Mowbray, S L.]]
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[[Category: Mowbray SL]]
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[[Category: Salopek-Sondi, B.]]
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[[Category: Salopek-Sondi B]]
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[[Category: Abc transport system]]
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[[Category: Leucine-binding protein]]
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[[Category: Protein structure]]
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[[Category: Transport protein]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:11:33 2008''
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Current revision

L-leucine-binding protein with leucine bound

PDB ID 1usk

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