2fey

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{{Seed}}
 
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[[Image:2fey.png|left|200px]]
 
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==The structure of stem loop IV of Tetrahymena telomerase RNA==
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The line below this paragraph, containing "STRUCTURE_2fey", creates the "Structure Box" on the page.
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<StructureSection load='2fey' size='340' side='right'caption='[[2fey]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fey]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FEY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fey OCA], [https://pdbe.org/2fey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fey RCSB], [https://www.ebi.ac.uk/pdbsum/2fey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fey ProSAT]</span></td></tr>
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{{STRUCTURE_2fey| PDB=2fey | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Conserved domains within the RNA component of telomerase provide the template for reverse transcription, recruit protein components to the holoenzyme and are required for enzymatic activity. Among the functionally essential domains in ciliate telomerase RNA is stem-loop IV, which strongly stimulates telomerase activity and processivity even when provided in trans. The NMR structure of Tetrahymena thermophila stem-loop IV shows a highly structured distal stem-loop linked to a conformationally flexible template-proximal region by a bulge that severely kinks the entire RNA. Through extensive structure-function studies, we identify residues that contribute to both these structural features and to enzymatic activity, with no apparent effect on the binding of TERT protein. We propose that the bending induced by the GA bulge and the flexibility of the template-proximal region allow positioning of the prestructured apical loop during the catalytic cycle.
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===The structure of stem loop IV of Tetrahymena telomerase RNA===
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Structure of stem-loop IV of Tetrahymena telomerase RNA.,Chen Y, Fender J, Legassie JD, Jarstfer MB, Bryan TM, Varani G EMBO J. 2006 Jul 12;25(13):3156-66. Epub 2006 Jun 15. PMID:16778765<ref>PMID:16778765</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2fey" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16778765}}, adds the Publication Abstract to the page
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*[[Telomerase 3D structures|Telomerase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16778765 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16778765}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEY OCA].
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[[Category: Bryan TM]]
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[[Category: Chen Y]]
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==Reference==
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[[Category: Fender J]]
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Structure of stem-loop IV of Tetrahymena telomerase RNA., Chen Y, Fender J, Legassie JD, Jarstfer MB, Bryan TM, Varani G, EMBO J. 2006 Jul 12;25(13):3156-66. Epub 2006 Jun 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16778765 16778765]
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[[Category: Jarstfer MB]]
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[[Category: Bryan, T M.]]
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[[Category: Legassie JD]]
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[[Category: Chen, Y.]]
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[[Category: Varani G]]
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[[Category: Fender, J.]]
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[[Category: Jarstfer, M B.]]
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[[Category: Legassie, J D.]]
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[[Category: Varani, G.]]
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[[Category: Heptaloop]]
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[[Category: Nmr structure]]
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[[Category: Stem-loop iv]]
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[[Category: Telomerase rna]]
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[[Category: Tetrahymena]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:11:47 2008''
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Current revision

The structure of stem loop IV of Tetrahymena telomerase RNA

PDB ID 2fey

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