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25c8

From Proteopedia

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{{Seed}}
 
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[[Image:25c8.png|left|200px]]
 
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==CATALYTIC ANTIBODY 5C8, FAB-HAPTEN COMPLEX==
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The line below this paragraph, containing "STRUCTURE_25c8", creates the "Structure Box" on the page.
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<StructureSection load='25c8' size='340' side='right'caption='[[25c8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[25c8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=25C8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=25C8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GEP:N-METHYL-N-(PARA-GLUTARAMIDOPHENYL-ETHYL)-PIPERIDINIUM+ION'>GEP</scene></td></tr>
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{{STRUCTURE_25c8| PDB=25c8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=25c8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=25c8 OCA], [https://pdbe.org/25c8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=25c8 RCSB], [https://www.ebi.ac.uk/pdbsum/25c8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=25c8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IGKC_MOUSE IGKC_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/5c/25c8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=25c8 ConSurf].
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<div style="clear:both"></div>
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===CATALYTIC ANTIBODY 5C8, FAB-HAPTEN COMPLEX===
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==See Also==
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10353817}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10353817 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10353817}}
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==About this Structure==
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25C8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=25C8 OCA].
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==Reference==
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Structural basis for antibody catalysis of a disfavored ring closure reaction., Gruber K, Zhou B, Houk KN, Lerner RA, Shevlin CG, Wilson IA, Biochemistry. 1999 Jun 1;38(22):7062-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10353817 10353817]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Gruber K]]
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[[Category: Gruber, K.]]
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[[Category: Wilson IA]]
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[[Category: Wilson, I A.]]
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[[Category: Catalytic antibody]]
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[[Category: Fab]]
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[[Category: Ring closure reaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:21:19 2008''
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Current revision

CATALYTIC ANTIBODY 5C8, FAB-HAPTEN COMPLEX

PDB ID 25c8

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