1x1z

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==Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump)==
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[[Image:1x1z.png|left|200px]]
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<StructureSection load='1x1z' size='340' side='right' caption='[[1x1z]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1x1z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"methanobacterium_thermoautotrophicus"_(sic)_zeikus_and_wolfe_1972 "methanobacterium thermoautotrophicus" (sic) zeikus and wolfe 1972]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X1Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X1Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dv7|1dv7]], [[1dvj|1dvj]], [[1kly|1kly]], [[1klz|1klz]], [[1km0|1km0]], [[1km1|1km1]], [[1km2|1km2]], [[1km3|1km3]], [[1km4|1km4]], [[1km5|1km5]], [[1km6|1km6]], [[1lol|1lol]], [[1loq|1loq]], [[1lor|1lor]], [[1los|1los]], [[1lp6|1lp6]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x1z OCA], [http://pdbe.org/1x1z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x1z RCSB], [http://www.ebi.ac.uk/pdbsum/1x1z PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PYRF_METTH PYRF_METTH]] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x1/1x1z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x1z ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Orotidine-5'-monophosphate decarboxylase (ODCase) has evolved to catalyze a decarboxylation reaction, most probably via a carbanion species at the C6 position of orotidine-5'-monophosphate. We reveal an unusual biochemical pathway of conversion of 6-cyano-uridine-5'-monophosphate by ODCase to barbiturate-5'-monophosphate via perhaps an electrophilic center at the C6 position, leading to inhibition. This potential of ODCase is very useful in the design of novel inhibitors.
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<!--
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An unprecedented twist to ODCase catalytic activity.,Fujihashi M, Bello AM, Poduch E, Wei L, Annedi SC, Pai EF, Kotra LP J Am Chem Soc. 2005 Nov 2;127(43):15048-50. PMID:16248642<ref>PMID:16248642</ref>
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The line below this paragraph, containing "STRUCTURE_1x1z", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_1x1z| PDB=1x1z | SCENE= }}
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===Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1x1z" style="background-color:#fffaf0;"></div>
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<!--
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_16248642}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 16248642 is the PubMed ID number.
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__TOC__
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-->
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</StructureSection>
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{{ABSTRACT_PUBMED_16248642}}
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==About this Structure==
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1X1Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X1Z OCA].
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==Reference==
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An unprecedented twist to ODCase catalytic activity., Fujihashi M, Bello AM, Poduch E, Wei L, Annedi SC, Pai EF, Kotra LP, J Am Chem Soc. 2005 Nov 2;127(43):15048-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16248642 16248642]
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[[Category: Methanothermobacter thermautotrophicus]]
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[[Category: Orotidine-5'-phosphate decarboxylase]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
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[[Category: Single protein]]
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[[Category: Annedi, S C]]
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[[Category: Annedi, S C.]]
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[[Category: Bello, A M]]
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[[Category: Bello, A M.]]
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[[Category: Fujihashi, M]]
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[[Category: Fujihashi, M.]]
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[[Category: Kotra, L P]]
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[[Category: Kotra, L P.]]
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[[Category: Pai, E F]]
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[[Category: Pai, E F.]]
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[[Category: Poduch, E]]
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[[Category: Poduch, E.]]
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[[Category: Wei, L]]
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[[Category: Wei, L.]]
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[[Category: 6-cyanoump]]
[[Category: 6-cyanoump]]
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[[Category: Lyase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:24:59 2008''
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Current revision

Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump)

1x1z, resolution 1.45Å

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