1qxm

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{{Seed}}
 
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[[Image:1qxm.png|left|200px]]
 
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==Crystal structure of a hemagglutinin component (HA1) from type C Clostridium botulinum==
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The line below this paragraph, containing "STRUCTURE_1qxm", creates the "Structure Box" on the page.
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<StructureSection load='1qxm' size='340' side='right'caption='[[1qxm]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qxm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum_D_phage Clostridium botulinum D phage]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QXM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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{{STRUCTURE_1qxm| PDB=1qxm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qxm OCA], [https://pdbe.org/1qxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qxm RCSB], [https://www.ebi.ac.uk/pdbsum/1qxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qxm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HA33D_CBDP HA33D_CBDP] The hemagglutinin (HA) component of the progenitor toxin protects the structural integrity of the neurotoxin; may increase internalization of the neurotoxin into the bloodstream of the host. Involved in binding to the small intestine through interactions with glycolipids and glycoproteins containing sialic acid moieties (By similarity). Erythrocyte agglutination only occurs when the entire complex is assembled (PubMed:17581814). Binds eukaryotic host mucins as well as N-acetyl-beta-neuraminic acid, N-acetyl-D-galactosamine and galactose (but not glucose) via 2 sites (By similarity).[UniProtKB:P0DPR0]<ref>PMID:17581814</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qx/1qxm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qxm ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of a hemagglutinin component (HA1) from type C Clostridium botulinum===
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==See Also==
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_14663070}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 14663070 is the PubMed ID number.
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</StructureSection>
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[[Category: Clostridium botulinum D phage]]
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{{ABSTRACT_PUBMED_14663070}}
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[[Category: Large Structures]]
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[[Category: Inoue K]]
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==About this Structure==
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[[Category: Negishi M]]
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1QXM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum_d_phage Clostridium botulinum d phage]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXM OCA].
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[[Category: Oguma K]]
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[[Category: Pedersen LC]]
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==Reference==
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[[Category: Sobhany M]]
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Structural analysis by X-ray crystallography and calorimetry of a haemagglutinin component (HA1) of the progenitor toxin from Clostridium botulinum., Inoue K, Sobhany M, Transue TR, Oguma K, Pedersen LC, Negishi M, Microbiology. 2003 Dec;149(Pt 12):3361-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14663070 14663070]
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[[Category: Transue TR]]
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[[Category: Clostridium botulinum d phage]]
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[[Category: Single protein]]
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[[Category: Inoue, K.]]
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[[Category: Negishi, M.]]
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[[Category: Oguma, K.]]
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[[Category: Pedersen, L C.]]
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[[Category: Sobhany, M.]]
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[[Category: Transue, T R.]]
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[[Category: Clostridium botulinum]]
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[[Category: Ha1]]
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[[Category: Hemagglutinin]]
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[[Category: Trefoil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:32:32 2008''
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Current revision

Crystal structure of a hemagglutinin component (HA1) from type C Clostridium botulinum

PDB ID 1qxm

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