3bl6

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{{Seed}}
 
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[[Image:3bl6.png|left|200px]]
 
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==Crystal structure of Staphylococcus aureus 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase in complex with formycin A==
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The line below this paragraph, containing "STRUCTURE_3bl6", creates the "Structure Box" on the page.
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<StructureSection load='3bl6' size='340' side='right'caption='[[3bl6]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bl6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BL6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMC:(1S)-1-(7-AMINO-1H-PYRAZOLO[4,3-D]PYRIMIDIN-3-YL)-1,4-ANHYDRO-D-RIBITOL'>FMC</scene></td></tr>
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{{STRUCTURE_3bl6| PDB=3bl6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bl6 OCA], [https://pdbe.org/3bl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bl6 RCSB], [https://www.ebi.ac.uk/pdbsum/3bl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bl6 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of Staphylococcus aureus 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase in complex with formycin A===
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== Function ==
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[https://www.uniprot.org/uniprot/MTNN_STAAM MTNN_STAAM] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18453700 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/3bl6_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18453700}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3BL6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BL6 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bl6 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structure of Staphylococcus aureus 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase., Siu KK, Lee JE, Smith GD, Horvatin-Mrakovcic C, Howell PL, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt, 5):343-50. Epub 2008 Apr 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18453700 18453700]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Horvatin, C.]]
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[[Category: Horvatin C]]
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[[Category: Howell, P L.]]
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[[Category: Howell PL]]
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[[Category: Lee, J E.]]
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[[Category: Lee JE]]
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[[Category: Siu, K K.W.]]
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[[Category: Siu KKW]]
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[[Category: Smith, G D.]]
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[[Category: Smith GD]]
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[[Category: Alpha and beta protein]]
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[[Category: Hydrolase]]
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[[Category: Mtan]]
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[[Category: Nucleosidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:33:40 2008''
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Current revision

Crystal structure of Staphylococcus aureus 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase in complex with formycin A

PDB ID 3bl6

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