1nko

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:17, 21 November 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1nko.png|left|200px]]
 
-
<!--
+
==Energetic and structural basis of sialylated oligosaccharide recognition by the natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7==
-
The line below this paragraph, containing "STRUCTURE_1nko", creates the "Structure Box" on the page.
+
<StructureSection load='1nko' size='340' side='right'caption='[[1nko]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1nko]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NKO FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nko OCA], [https://pdbe.org/1nko PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nko RCSB], [https://www.ebi.ac.uk/pdbsum/1nko PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nko ProSAT]</span></td></tr>
-
{{STRUCTURE_1nko| PDB=1nko | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SIGL7_HUMAN SIGL7_HUMAN] Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).<ref>PMID:10611343</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nk/1nko_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nko ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The high-resolution crystal structure of the functional N-terminal domain from the extracellular region of the human natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7 has been determined at 1.45 A resolution; it was obtained from a crystal belonging to a primitive monoclinic space group, with unit-cell parameters a = 32.65, b = 49.72, c = 39.79 A, alpha = gamma = 90, beta = 113 degrees. The structure reported here belongs to a different space group than the previously described Siglec-7 structure and was obtained using a bacterial expression system. The structure unveils the fine structural requirements adopted by a natural killer cell inhibitory receptor of the Siglec family in target-cell recognition and binding.
-
===Energetic and structural basis of sialylated oligosaccharide recognition by the natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7===
+
Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1.,Dimasi N, Moretta A, Moretta L, Biassoni R, Mariuzza RA Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):401-3. Epub 2004, Jan 23. PMID:14747738<ref>PMID:14747738</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_14747738}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1nko" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 14747738 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_14747738}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
1NKO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKO OCA].
+
-
 
+
-
==Reference==
+
-
Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1., Dimasi N, Moretta A, Moretta L, Biassoni R, Mariuzza RA, Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):401-3. Epub 2004, Jan 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14747738 14747738]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Aalten, D M.F van.]]
+
[[Category: Attril H]]
-
[[Category: Attril, H.]]
+
[[Category: Biassoni R]]
-
[[Category: Biassoni, R.]]
+
[[Category: Dimasi N]]
-
[[Category: Dimasi, N.]]
+
[[Category: Mariuzza RA]]
-
[[Category: Mariuzza, R A.]]
+
[[Category: Moretta L]]
-
[[Category: Moretta, L.]]
+
[[Category: Van Aalten DMF]]
-
[[Category: Immunoglobulin]]
+
-
[[Category: Siglec7]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:46:11 2008''
+

Current revision

Energetic and structural basis of sialylated oligosaccharide recognition by the natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7

PDB ID 1nko

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nko"
Personal tools