1nj8

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{{Seed}}
 
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[[Image:1nj8.png|left|200px]]
 
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==Crystal Structure of Prolyl-tRNA Synthetase from Methanocaldococcus janaschii==
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The line below this paragraph, containing "STRUCTURE_1nj8", creates the "Structure Box" on the page.
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<StructureSection load='1nj8' size='340' side='right'caption='[[1nj8]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nj8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NJ8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nj8 OCA], [https://pdbe.org/1nj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nj8 RCSB], [https://www.ebi.ac.uk/pdbsum/1nj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nj8 ProSAT]</span></td></tr>
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{{STRUCTURE_1nj8| PDB=1nj8 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYP_METJA SYP_METJA] Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Can inadvertently accommodate and process non-cognate amino acids such as cysteine and alanine.<ref>PMID:10642548</ref> <ref>PMID:10869184</ref> <ref>PMID:11141055</ref> <ref>PMID:11866507</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nj/1nj8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nj8 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Prolyl-tRNA Synthetase from Methanocaldococcus janaschii===
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12578991}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12578991 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_12578991}}
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==About this Structure==
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1NJ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJ8 OCA].
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==Reference==
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The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases., Kamtekar S, Kennedy WD, Wang J, Stathopoulos C, Soll D, Steitz TA, Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1673-8. Epub 2003 Feb 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12578991 12578991]
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[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Proline--tRNA ligase]]
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[[Category: Kamtekar S]]
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[[Category: Single protein]]
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[[Category: Kennedy WD]]
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[[Category: Kamtekar, S.]]
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[[Category: Soll D]]
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[[Category: Kennedy, W D.]]
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[[Category: Stathopoulos C]]
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[[Category: Soll, D.]]
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[[Category: Steitz TA]]
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[[Category: Stathopoulos, C.]]
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[[Category: Wang J]]
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[[Category: Steitz, T A.]]
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[[Category: Wang, J.]]
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[[Category: Class-ii trna synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:47:19 2008''
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Current revision

Crystal Structure of Prolyl-tRNA Synthetase from Methanocaldococcus janaschii

PDB ID 1nj8

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